Adaptation to High Altitude in Sherpas: Association with the Insertion/Deletion Polymorphism in the Angiotensin-Converting Enzyme Gene Yunden Droma,

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Presentation transcript:

Adaptation to High Altitude in Sherpas: Association with the Insertion/Deletion Polymorphism in the Angiotensin-Converting Enzyme Gene Yunden Droma, MD, PhD, Masayuki Hanaoka, MD, PhD, Buddha Basnyat, MD, Amit Arjyal, MD, Pritam Neupane, MD, Anil Pandit, MD, Dependra Sharma, MD, Michiko Ito, MD, Naoyuki Miwa, MD, Yoshihiko Katsuyama, PhD, Masao Ota, PhD, Keishi Kubo, MD, PhD Wilderness & Environmental Medicine Volume 19, Issue 1, Pages 22-29 (March 2008) DOI: 10.1580/06-WEME-OR-073.1 Copyright © 2008 Wilderness Medical Society Terms and Conditions

Figure Graph of serum ACE activity according to the ACE I/D polymorphism in Sherpas and non-Sherpas.† The ACE activity in both populations is correlated with the genotypes, being significantly highest in the subjects with DD genotype, intermediate in ID heterozygotes, and lowest in II homozygotes. *P<.001 compared with the II homozygotes. The number of subjects is shown in parentheses. †Non-Sherpas indicates non-Sherpa Nepalese residing in Kathmandu Valley, Nepal. Wilderness & Environmental Medicine 2008 19, 22-29DOI: (10.1580/06-WEME-OR-073.1) Copyright © 2008 Wilderness Medical Society Terms and Conditions