Interleukins and Atherosclerosis: A Dysfunctional Family Grows

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Presentation transcript:

Interleukins and Atherosclerosis: A Dysfunctional Family Grows Larry D. Spears, Babak Razani, Clay F. Semenkovich Cell Metabolism Volume 18, Issue 5, Pages 614-616 (November 2013) DOI: 10.1016/j.cmet.2013.10.009 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Inflammatory Cytokines Promote Atherosclerosis Macrophages secrete IL-1β (bottom), which is thought to be important in this process, but recent evidence implicates IL-1α (top) through a mechanism involving fatty acid-induced respiratory uncoupling and alterations of calcium flux. Cell Metabolism 2013 18, 614-616DOI: (10.1016/j.cmet.2013.10.009) Copyright © 2013 Elsevier Inc. Terms and Conditions