Outcomes with trisodium citrate 30% vs heparin as catheter-locking solution (all catheters) in patients on hemodialysis Variable TSC, n (%) Heparin, n.

Slides:



Advertisements
Similar presentations
Infectious complications of hemodialysis catheters
Advertisements

Zuragen® Lock (an investigational device)
Le malattie immunitarie aumentano il rischio di complicanze infettive? Gianfranca Cabiddu Divisione Nefrologia Azienda Ospedaliera Brotzu- Cagliari.
Flow Diagram of Identification of Randomized Trials for Inclusion Goran Bjelakovic, et al. JAMA. 2007;297:
Infectious complications during dialysis. Scope  Infectious disease in dialysis Epidemiology and importance Epidemiology and importance Diagnosis and.
Acute Renal Failure in HIV- Infected Individuals Greatly Increases Risk for In-Hospital Mortality Slideset on: Wyatt CM, Arons RR, Klotman PE, Klotman.
The AURORA Trial Source: Holdaas H, Holme I, Schmieder RE, et al. Rosuvastatin in diabetic hemodialysis patient. J Am Soc Nephrol. 2011;22(7):1335–1341.
Long Term Peritoneal Dialysis In Children – Frequent Complications Conclusions: Peritoneal Dialysis is the method of choice for pediatric patients, with.
Renal Replacement Therapy for Prevention of Contrast- induced Acute Kidney Injury: A Meta-analysis of Randomized Controlled Trials Source Song K, Jiang.
Nephrology Specialist at New Mansoura General Hospital
LEADER trial: Primary Outcome
Anti-Infective Locks for Treatment of Central Line-Associated Bloodstream Infection: A Systematic Review and Meta-Analysis Am J Nephrol 2011;34:415–422.
SOCRATES Trial design: Patients with acute ischemic stroke were randomized in a 1:1 fashion to receive either ticagrelor 180 mg load + 90 mg BID or aspirin.
Intensive Hemodialysis, Treatment Complications and Tolerability
Hospital admissions per patient, by modality figure 5
Effect of Obesity on In-Hospital Mortality in Patients with Cardiogenic Shock Complicating AMI Obesity is paradoxically associated with favorable mortality.
Checklist for Site Reconnaissance (Sabatini et al_2002)
Effects of High Density Lipoprotein Raising Therapies on Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus, with or without Renal Impairment:
CHOICE: Relative risk of death on peritoneal dialysis vs hemodialysis
Relative mortality risk associated with quartiles of systolic blood pressure compared with systolic
Nurses' Health Study: Risk of hypertension associated with >1000 µg/day of folate vs
Fan et al. Am J Nephrol 2017;45:   (DOI: / )
HICKMAN CATHETER. HICKMAN CATHETER Thrombotic complications associated with venous access devices Occlusion of lumen Fibrin sheath formation Venous.
Adjusted relative mortality risk
Baseline characteristics of patients
Bushinsky et al. Am J Nephrol 2016;44: (DOI: / )
Figures for Jerrett et al. EDE –
Impact of Cognitive Function Change on Mortality in Renal Transplant and End-Stage Renal Disease Patients Sharma et al. Am J Nephrol 2016;44: (DOI: / )
PREMIER: Rate of hypertension at 18 months
CHOICE study: Relative hazard of ASCVD events by baseline levels of Lp(a), LMW ApoA isoforms, and LMW ApoA isoforms with high Lp(a) vs high-molecular-weight.
Dabigatran vs Warfarin in Patients with Atrial Fibrillation – Results
Hammoud et al. Am J Nephrol 2016;44:  (DOI: / )
A Six-hour Hemodialysis Without a Significant Increase in Dialysis Dose, as Judged by Kt/V, Can Reduce the Dosage of Erythropoietin Department of Kidney.
Relative risk of major events with atenolol vs placebo
Outcome Relative risk with beta blockers 95% CI Stroke –1.30
Health ABC: Mortality risk by quintile of cystatin C
Risk of perioperative renal dysfunction with N-acetylcysteine or placebo in patients undergoing CABG surgery End point N-acetylcysteine Placebo Relative.
End point Fenoldopam, n (%) Dopamine, n (%) p
Erratum Regarding “Ultrasound Monitoring to Detect Access Stenosis in Hemodialysis Patients: A Systematic Review” (Am J Kidney Dis. 2008;51(4): ) 
Mancini JG, et al. Am J Cardiol.
Outcomes with dual RAAS inhibition with an ACE inhibitor and ARB vs standard therapy in patients on hemodialysis with CHF standard therapy in patients.
CKD cohort Non-CKD cohort Test Entire cohort, n=24 778
Relative risk reduction for incident hypertension associated with weight loss of 6.8 kg: The Framingham Study Cohort Risk reduction (%) Relative risk.
Volume 61, Issue 3, Pages (March 2002)
Forest plot of risk ratio with its 95% CI for the incidence of contrast-induced nephropathy among patient taking statin versus control based on renal impairment.
Predictors of disease progression in patients with CKD
Cystatin C levels and risk of death from all causes
Effects of Daprodustat, a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Anemia Management in Japanese Hemodialysis Subjects Akizawa et.
Adjusted relative risk for developing end-stage renal disease (ESRD) associated with blood-pressure level BP level (mm Hg) Adjusted relative risk 95%
Baseline Characteristics of Cardiovascular Risk Factors and Selected Dietary Variables in a Cohort of 22,881 Men and 35,091 Women to Quintile of Fish Intakes.
Patient characteristics: American vs Canadian transplant patients
Berger JS, et al. JAMA 2009;301:
CRRT dialysis circuit using regional citrate anticoagulation with the Gambro Prisma machine. CRRT dialysis circuit using regional citrate anticoagulation.
Daniel L. Landry, DO, FASN  Advances in Chronic Kidney Disease 
Microbiology and outcomes of peritonitis in North America
DANAMI 3-DEFER Trial design: Patients presenting with STEMI and in whom the operators could establish TIMI 2-3 flow without stenting or those presenting.
Comparison of Low-Dose Gentamicin With Minocycline as Catheter Lock Solutions in the Prevention of Catheter-Related Bacteremia  Uday S. Nori, MD, Anup.
Universal Sustained Viral Response to the Combination of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir with/without Ribavirin in Patients on Hemodialysis.
ASCOT: randomised trial showing a decrease in cardiovascular mortality in patients treated with amlodipine/perindopril compared with atenolol/thiazide.
Kaplan–Meier curve for technique survival censored for death, transplantation, and program exit for patient choice for all individuals commencing home.
Volume 56, Pages S37-S40 (November 1999)
EMPA-REG OUTCOME: Cumulative incidence of the primary outcome
Davide Capodanno et al. JCIN 2009;2:
Meta-analysis of risk ratios for percentage of patients who developed catheter-associated urinary tract infection, for intervention versus control groups,
Meta-analysis of risk ratios for percentage of patients who developed catheter-associated urinary tract infection, for intervention versus control groups,
Risk for cardiovascular disease and all-cause death according to RHR: (A) as categorical variable (HR≥75 bpm vs HR
Álvares et al. Am J Nephrol 2017;45: (DOI: / )
Pooled estimate of relative risk and 95% CIs of colorectal cancer associated with metformin therapy based on four studies comprising 107,961 diabetic patients.
Fistula and Survival Outcomes after Fistula Creation among Predialysis Chronic Kidney Disease Stage 5 Patients Miyamoto et al. Am J Nephrol 2017;45:  
Associations of dialysis session length with mortality and hospitalizations. Associations of dialysis session length with mortality and hospitalizations.
Presentation transcript:

Outcomes with trisodium citrate 30% vs heparin as catheter-locking solution (all catheters) in patients on hemodialysis Variable TSC, n (%) Heparin, n (%) Relative risk (95% CI) p CRB 9 (6) 33 (23) 0.25 (0.12-0.52) <0.001 Death from CRB 5 0.96 (0.93-0.99) 0.028 Removal for any complication 42 (28) 66 (46) 0.57 (0.38-0.85) Exit-site infection 11 (7) 32 (22) 0.41 (0.20-0.81) 0.012 Removal for flow problems 27 (18) 29 (20) 0.92 (0.54-1.55) 0.75 Catheters treated with urokinase 69 (47) 63 (44) 1.11 (0.70-1.75) 0.72 Weijmer M et al. J Am Soc Nephrol 2005; Available at http://jasn.asnjournals.org.