Jeffrey F. Barletta, PharmD, Shareen Y. El-Ibiary, PharmD, Lindsay E

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Proton Pump Inhibitors and the Risk for Hospital-Acquired Clostridium difficile Infection Jeffrey F. Barletta, PharmD, Shareen Y. El-Ibiary, PharmD, Lindsay E. Davis, PharmD, Bao Nguyen, PharmD, Carrington R. Raney, PharmD Mayo Clinic Proceedings Volume 88, Issue 10, Pages 1085-1090 (October 2013) DOI: 10.1016/j.mayocp.2013.07.004 Copyright © 2013 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 1 Incidence of Clostridium difficile infection (CDI) characterized by duration of proton pump inhibitor (PPI) usage and total number of antibiotics received. P values above each bar represent comparisons of duration of PPI therapy within each group for total number of antibiotics received. For comparisons between total number of antibiotics received within each group for duration of PPI therapy: aP=.579 for comparison of total number of antibiotics received within the cohort of patients receiving 0 to 2 days of PPI therapy; bP=.317 for comparison of total number of antibiotics received within the cohort of patients receiving 3 to 12 days of PPI therapy; cP>.99 for comparison of total number of antibiotics received within the cohort of patients receiving 13 or more days of PPI therapy. Mayo Clinic Proceedings 2013 88, 1085-1090DOI: (10.1016/j.mayocp.2013.07.004) Copyright © 2013 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 2 Decision tree illustrating the risk for hospital-acquired Clostridium difficile infection (CDI). For pairwise comparisons: aP=.001; bP<.001; cP=.053. PPI = proton pump inhibitor. Mayo Clinic Proceedings 2013 88, 1085-1090DOI: (10.1016/j.mayocp.2013.07.004) Copyright © 2013 Mayo Foundation for Medical Education and Research Terms and Conditions