Developmental biology informs cancer

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Developmental biology informs cancer Keping Xie, James L Abbruzzese Cancer Cell Volume 4, Issue 4, Pages 245-247 (October 2003) DOI: 10.1016/S1535-6108(03)00246-0

Figure 1 Hedgehog signaling, carcinogenesis, and potential therapeutic targets Upregulation of Hh ligands may be mediated by epigenetic events. Mutations in PTCH and SHOH result in activation of hedgehog signaling and are causative in basal cell carcinoma and medulloblastoma. Gli proteins are thought to mediate activation of Hh transcriptional targets potentially important in tumorigenesis, progression, and metastasis. Abbreviations: SHh, sonic hedgehog; IHh, Indian hedgehog; DHh, desert hedgehog; HIP, hedgehog interacting protein; PTCH, patched; SMOH, smoothened; GLI; cubitus interruptus-like transcription factor involved in glioma formation. Cancer Cell 2003 4, 245-247DOI: (10.1016/S1535-6108(03)00246-0)