Organization of the Autonomic Nervous System-II

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Nervous system /'æfərənt/] /'efərənt/ /'visərəl/ /,simpə'θetik/
Presentation transcript:

Organization of the Autonomic Nervous System-II By Dr.Sajid Hussain Objectives Discuss autonomic receptor Know functional organization of ANS Describe receptors in correlations with their neurotransmitter and function

Muscarinic(M) & Nicotinic (N) receptors Autonomic receptors Adrenergic receptors Cholinergic reeptors Alfa (α) & beta(β) adrenoceptors Muscarinic(M) & Nicotinic (N) receptors

Adrenergic receptors

α –adrenergic receptors IP3- inositol triphosphate, DAG- Diacytl glycerol, cAMP- Cyclic Adenosine Monophsphate

Differences between α1 and α2

α1 and α2 α2 is an autoreceptor and inhibits NA release

β-receptors

β-receptor

Effects of β-receptor

Cholinergic / parasympathetic receptors

Muscarinic receptor

Funtional organization of parasympathetic system Bronchoconstriction, ↑ secretion ↓ HR, ↓ conductivity Miosis, ↓IOP, contraction of ciliary m ↑ Hcl secretion ↑secretion, peristalsis ↑ lacrimation ↑ contraction ↑ secretion & salivation Sphincter contraction ↑ secretion, salivation Erection in males

Functional organization of sympathetic system Mydriasis Thick secretions ↑HR and conduction ↑ sweating (Ach) bronchodilation relaxation Release of renin relaxation Ejaculation in males

Receptor correlation Neurotransmitter NA Neurotransmitter Ach

Receptor correlation Sympathetic Parasympathetic

summary

summary

References Lippincott’s Illustrated review of pharmacology – 4th edition Basic & clinical pharmacology, Bertram G katzung-12th edition Goodman & Gilman’s –pharmacology Internet resource

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