Staying on Course: Optimizing Antiepileptic Medication Regimens

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Presentation transcript:

Staying on Course: Optimizing Antiepileptic Medication Regimens

Program Overview

The Burden of Epilepsy

AEDs and Switching

MHRA Safety Update in the United Kingdom: Risk-Based Categories for Switching Products

AEDs: Different Preparations

Adverse Effects of AEDs

Pharmacologic Factors

Bioequivalence vs Therapeutic Equivalence: Regulations Covering Licensing of Generic Products

Issues of Concern About Generic Substitution of AEDs Identified in a Literature Review

Survey of Neurologists on Experience With Switching Patients to a Generic AED

Breakthrough Seizures Can Affect Patient QoL

Consequences of Generic AED Substitution: Survey of Neurologists

Design of AED Switching Studies

Comparative Effectiveness of Brand vs Generic AEDs

Meta-analysis of 7 RCTs of Brand vs Generic AEDs: Odds of Uncontrolled Seizure

Odds of a Seizure-Related Event Higher in Patients Switching Between Bioequivalent AEDs

Association Between AED Refill and Switch and Seizure-Related Events

Studies of Switching Back From a Generic to a Brand AED

Evidence for 2 Seizure-Free Years Before Withdrawing AEDs in Children

AED Substitution: International Experience

Factors Affecting Seizure Control

Take-Home Messages

Abbreviations