Regulatory Subunits of Energy-Dependent Proteases

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Regulatory Subunits of Energy-Dependent Proteases Susan Gottesman, Michael R Maurizi, Sue Wickner  Cell  Volume 91, Issue 4, Pages 435-438 (November 1997) DOI: 10.1016/S0092-8674(00)80428-6

Figure 1 Steps for Regulation of ATP-Dependent Protein Degradation A model for the ATP-dependent degradation pathway is shown for a generic Clp-like protease, composed of a Clp ATPase component (shown in blue) and a proteolytic component (shown in green). The substrate is shown in red. The alternate pathway of protein remodeling by the ATPase component is also shown. We would predict similarities in the degradation pathways for both the 26S protease and the homomeric Lon and FtsH families of proteases. See the text for full discussion of these steps. Cell 1997 91, 435-438DOI: (10.1016/S0092-8674(00)80428-6)