Novel chromosomal imbalances in mantle cell lymphoma detected by genome-wide array-based comparative genomic hybridization by Margit Schraders, Rolph Pfundt,

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Novel chromosomal imbalances in mantle cell lymphoma detected by genome-wide array-based comparative genomic hybridization by Margit Schraders, Rolph Pfundt, Huub M. P. Straatman, Irene M. Janssen, Ad Geurts van Kessel, Eric F. P. M. Schoenmakers, Johan H. J. M. van Krieken, and Patricia J. T. A. Groenen Blood Volume 105(4):1686-1693 February 15, 2005 ©2005 by American Society of Hematology

Schematic representation of the chromosomal imbalances previously reported in classic CGH studies. Schematic representation of the chromosomal imbalances previously reported in classic CGH studies. Gains are shown in light gray and losses in dark gray. The centromere is represented by an arrowhead. MB positions and chromosome bands were determined with the UCSC genome browser (April 2003 freeze). When consecutive areas of the same case were less then 5 BAC clones apart and these clones had a mean similar to the mean of the consecutive areas, they were combined in 1 consecutive area. The most overlapping aberrations were loss of 1p, 11q, 13q, plus gain of 3q and 8q. Margit Schraders et al. Blood 2005;105:1686-1693 ©2005 by American Society of Hematology

Schematic representation of novel chromosomal imbalances in MCL cases. Schematic representation of novel chromosomal imbalances in MCL cases. Gains are shown in light gray and losses in dark gray. The centromere is represented by an arrowhead. MB positions and chromosome bands were determined with the UCSC genome browser (April 2003 freeze). When consecutive areas of the same case were less than 5 BAC clones apart and these clones had a mean similar to the mean of the consecutive areas, they were combined in 1 consecutive area. The minimal overlapping regions identified in these chromosomes are 4p12-13, 20p12.1-12.3, 20q12-13.12, 22q12.1-12.3, and 22q13.31-13.32. Margit Schraders et al. Blood 2005;105:1686-1693 ©2005 by American Society of Hematology

Genomic profiles of MCL cases. Genomic profiles of MCL cases. Data are plotted as the mean log2 ratios over reference ratios. BACS are ordered by position over the genome from 1 to Y. BAC positions were determined with the UCSC genome browser (April 2003 freeze). The primary tumor (MC50) and subsequent relapses (MC51-MC53) from the same patient show a similar genomic profile. Margit Schraders et al. Blood 2005;105:1686-1693 ©2005 by American Society of Hematology