Relationship among human herpesvirus 6 reactivation, serum interleukin 10 levels, and rash/graft-versus-host disease after allogeneic stem cell transplantation

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Presentation transcript:

Relationship among human herpesvirus 6 reactivation, serum interleukin 10 levels, and rash/graft-versus-host disease after allogeneic stem cell transplantation Kana Kitamura, MD, Hideo Asada, MD, PhD, Hideyuki Iida, MD, Takaya Fukumoto, MD, PhD, Nobuhiko Kobayashi, MD, PhD, Hironori Niizeki, MD, PhD, Takeshi Morii, MD, PhD, Hiroshi Kimura, MD, PhD, Sachiko Miyagawa, MD, PhD Journal of the American Academy of Dermatology Volume 58, Issue 5, Pages 802-809 (May 2008) DOI: 10.1016/j.jaad.2008.01.005 Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Case 8. Clinical and histologic findings. A and B, Macular/papular rash on trunk, appearing on day 32 after allo-SCT. C and D, Sparse lymphocytic infiltration of upper dermis with exocytosis of lymphocytes into epidermis. (C and D, Hematoxylin-eosin stain; original magnifications: C,×100; D, ×200.) Journal of the American Academy of Dermatology 2008 58, 802-809DOI: (10.1016/j.jaad.2008.01.005) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Case 7. Clinical and histologic findings. A and B, Acute disseminated macular/papular rash, appearing on day 27 after allo-SCT. C and D, Established acute GVHD of the skin. Lymphocytic interface dermatitis and multiple eosinophilic keratinocytes. (C and D, Hematoxylin-eosin stain; original magnifications: C, ×100; D, ×200.) Journal of the American Academy of Dermatology 2008 58, 802-809DOI: (10.1016/j.jaad.2008.01.005) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 HHV-6 DNA levels in the whole blood (solid circle) and sera (open circle), hepatic enzyme (triangle), and rash (shaded area) after allo-SCT. Dagger indicates death of patient. Journal of the American Academy of Dermatology 2008 58, 802-809DOI: (10.1016/j.jaad.2008.01.005) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

Fig 4 Relationship among serum IL-10 (picograms per milliliter of serum) and sIL-2R levels (units per milliliter of serum), HHV-6 DNA levels (number of copies per 106 lymphocytes), and rash. Dagger indicates death of patient. Journal of the American Academy of Dermatology 2008 58, 802-809DOI: (10.1016/j.jaad.2008.01.005) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions