Bacterial lipopolysaccharide directly induces angiogenesis through TRAF6-mediated activation of NF-κB and c-Jun N-terminal kinase by Ingrid Pollet, Christy.

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Bacterial lipopolysaccharide directly induces angiogenesis through TRAF6-mediated activation of NF-κB and c-Jun N-terminal kinase by Ingrid Pollet, Christy J. Opina, Carla Zimmerman, Kevin G. Leong, Fred Wong, and Aly Karsan Blood Volume 102(5):1740-1742 September 1, 2003 ©2003 by American Society of Hematology

LPS signals endothelial sprouting through a TRAF6-mediated pathway that activates NF-κB and JNK. Microcarrier beads seeded with endothelial cells were embedded in fibrin gels and exposed to various stimuli. LPS signals endothelial sprouting through a TRAF6-mediated pathway that activates NF-κB and JNK. Microcarrier beads seeded with endothelial cells were embedded in fibrin gels and exposed to various stimuli. (A) An example of endothelial sprouts (arrows) formed in this assay following LPS (100 ng/mL) stimulation. (B) Quantitation of the number of sprouts formed following stimulation by serum-only (control), bFGF (1 ng/mL), LPS (100 ng/mL), or TNF (10 ng/mL). Effect of inhibiting (C) TRAF6 activation, (D) NF-κB activation, or (E) JNK activation on endothelial sprouting in response to bFGF (1 ng/mL) or LPS (100 ng/mL). Each experiment was done in triplicate, and the total number of experiments done in each case is indicated on the graph. Results shown are the mean + SEM of the total number of experiments. *P ≤ .05, **P ≤ .01. Ingrid Pollet et al. Blood 2003;102:1740-1742 ©2003 by American Society of Hematology

Inhibition of TRAF6 signaling on the chick CAM inhibits LPS- but not bFGF-induced angiogenesis. Inhibition of TRAF6 signaling on the chick CAM inhibits LPS- but not bFGF-induced angiogenesis. Avian retroviral producer lines were used to infect the proliferating cells (mainly endothelial) on the chick CAM with either empty vector (CK) or a dominant-negative TRAF6 (CK-TRAF6-C). (A) A representative CAM showing LPS-induced angiogenesis following infection of the CAM by empty vector (left panel) or TRAF6-C (right panel). The arrows point to the corners of the mesh on which the retroviral producer lines are seeded. (B) Quantitation of vessel number entering the mesh following retroviral infection and stimulation with bFGF (30 ng/mL) or LPS (10 ng/mL). Results shown are the number of vessels entering the mesh perimeter over baseline control (medium only). The number of experiments for each condition is shown over the bars. Results shown are the mean + SEM. *P ≤ .05. Ingrid Pollet et al. Blood 2003;102:1740-1742 ©2003 by American Society of Hematology