Jean-Claude Bystryn, MD, Sergei A. Grando, MD, PhD, Dsci

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Presentation transcript:

A novel explanation for acantholysis in pemphigus vulgaris: The basal cell shrinkage hypothesis Jean-Claude Bystryn, MD, Sergei A. Grando, MD, PhD, Dsci Journal of the American Academy of Dermatology Volume 54, Issue 3, Pages 513-516 (March 2006) DOI: 10.1016/j.jaad.2005.12.003 Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Acantholysis begins in interdesmosomal areas. First evidence of acantholysis by electron microscopy is separation of adjacent keratinocytes from each other in areas of cell surface where there are no desmosomes. Cells appear to be pulling away from each other, coming apart at weakest point holding them together–between desmosomes. They are separating while desmosomes are still adhering to each other. T, tonofilaments. Reprinted by permission from Macmillan Publishers Ltd: J Invest Dermatol, Hashimoto and Lever.6 Copyright 1967. Journal of the American Academy of Dermatology 2006 54, 513-516DOI: (10.1016/j.jaad.2005.12.003) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions