Obesity, male infertility, and the sperm epigenome

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Presentation transcript:

Obesity, male infertility, and the sperm epigenome James R. Craig, M.D., Timothy G. Jenkins, Ph.D., Douglas T. Carrell, Ph.D., H.C.L.D., James M. Hotaling, M.D., M.S., F.E.C.S.M. Fertility and Sterility Volume 107, Issue 4, Pages 848-859 (April 2017) DOI: 10.1016/j.fertnstert.2017.02.115 Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Worldwide obesity incidence. Fertility and Sterility 2017 107, 848-859DOI: (10.1016/j.fertnstert.2017.02.115) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Obesity and male infertility: mechanisms. Obesity operates through multiple pathways to alter male reproductive potential. It creates epigenetic changes, some of which can influence subsequent generations. In addition, it alters the male androgenic axis, influences a host of other “neohormones,” and raises insulin levels. Finally, it has been linked to erectile dysfunction and causes stress, inflammation and sleep apnea, all of which can further reduce male fertility. Kp = kisspeptin. Fertility and Sterility 2017 107, 848-859DOI: (10.1016/j.fertnstert.2017.02.115) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions