IL-4 induces IL-13–independent allergic airway inflammation

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Presentation transcript:

IL-4 induces IL-13–independent allergic airway inflammation Charles Perkins, BA, Marsha Wills-Karp, PhD, Fred D. Finkelman, MD Journal of Allergy and Clinical Immunology Volume 118, Issue 2, Pages 410-419 (August 2006) DOI: 10.1016/j.jaci.2006.06.004 Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 IL-4C induces allergic airway inflammation in IL-13–deficient mice. Wild-type and IL-13–deficient mice were tested for airway responsiveness and then inoculated intratracheally daily for 7 days with IL-4C (2 μg of IL-4 + 10 μg of anti–IL-4 mAb per dose). Mice were retested for airway responsiveness on day 8, after which BAL was performed and PAS-stained lung sections were prepared. A, Means and SEs of BAL cells. Eosinophils are significantly increased in IL-4C–treated versus saline-treated wild-type and IL-13–deficient mice but similar in IL-4C–treated wild-type and IL-13–deficient mice. B, Airway responses (means and SEs) to methacholine. IL-4C caused a significant increase in methacholine responsiveness in IL-13–deficient mice. C, Percentages of bronchiolar epithelial cells that were PAS positive are shown for saline- and IL-4C–treated wild-type and IL-13–deficient mice. Percentages of PAS-positive cells are significantly increased in IL-4C–treated versus saline-treated wild-type and IL-13–deficient mice but do not differ significantly between IL-4C–treated groups. Journal of Allergy and Clinical Immunology 2006 118, 410-419DOI: (10.1016/j.jaci.2006.06.004) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Inhalation of IL-4C stimulates goblet cell hyperplasia in IL-13–deficient mice. PAS staining of lung sections from saline-inoculated wild-type mice (A), saline-inoculated IL-13–deficient mice (B), IL-4C–inoculated wild-type mice (C), and IL-4C–inoculated IL-13–deficient mice (D) are shown. Journal of Allergy and Clinical Immunology 2006 118, 410-419DOI: (10.1016/j.jaci.2006.06.004) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Inhalation of free IL-4 induces allergic airway inflammation in IL-13–deficient mice. The experiment shown in Figs 1 and 2 was repeated, with the exception that IL-4C was replaced by free IL-4 (10 μg per dose). Results show BAL cellularity (A), airway responsiveness (B), and percentage of PAS-positive bronchiolar epithelial cells (C). Journal of Allergy and Clinical Immunology 2006 118, 410-419DOI: (10.1016/j.jaci.2006.06.004) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 4 IL-4C induces allergic airway inflammation in IL-13 antagonist–treated mice. BALB/c mice were injected with soluble IL-13Rα2-Fc or control fusion protein and inoculated with saline or IL-4C, as in Fig 1. BAL eosinophil numbers (A), methacholine responsiveness (B), and percentages of PAS-positive bronchiolar epithelial cells (C) are all significantly increased in both groups of IL-4C–treated mice but not significantly affected by soluble IL-13Rα2-Fc. Journal of Allergy and Clinical Immunology 2006 118, 410-419DOI: (10.1016/j.jaci.2006.06.004) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 5 IL-13 antagonist does not prevent IL-4 induction of goblet cell hyperplasia. Lung sections made from the mice used for Fig 3 were PAS stained. Results from mice inoculated with saline-control fusion protein (A), saline/soluble IL-13Rα2-Fc (B), IL-4C/control fusion protein (C), and IL-4C/soluble IL-13Rα2-Fc (D) are shown. Journal of Allergy and Clinical Immunology 2006 118, 410-419DOI: (10.1016/j.jaci.2006.06.004) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 6 Anti–IL-4Rα mAb blocks IL-4 induction of AHR, BAL eosinophilia, and goblet cell hyperplasia. BALB/c mice were inoculated daily intratracheally with saline or IL-4C, as described for Fig 1, and injected intraperitoneally with 3 mg of anti–IL-4Rα mAb or an isotype-matched control mAb. Mice were evaluated for BAL cells (A), AHR (B), and goblet cell hyperplasia (C). Journal of Allergy and Clinical Immunology 2006 118, 410-419DOI: (10.1016/j.jaci.2006.06.004) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions