Is FMR1 CGG repeat length a predictor of in vitro fertilization stimulation response or outcome?  Nicole Banks, M.D., George Patounakis, M.D., Ph.D., Kate Devine, M.D., Alan H. DeCherney, M.D., Eric Widra, M.D., Eric D. Levens, M.D., Brian W. Whitcomb, Ph.D., Micah J. Hill, D.O.  Fertility and Sterility  Volume 105, Issue 6, Pages 1537-1546.e8 (June 2016) DOI: 10.1016/j.fertnstert.2016.02.011 Copyright © 2016 Terms and Conditions

Figure 1 Scatter plots demonstrating the weak association of (A) FMR1 short alleles and (B) FMR1 long alleles and oocyte yield, and the strong association of (C) antral follicle count and (D) antimüllerian hormone with oocyte yield. Fertility and Sterility 2016 105, 1537-1546.e8DOI: (10.1016/j.fertnstert.2016.02.011) Copyright © 2016 Terms and Conditions

Figure 2 Receiver operating characteristic (ROC) curves associating predictor variables with (A) poor ovarian response (<4 oocytes) and (B) hyper ovarian response (>15 oocytes). The area under the curve (AUC) is shown under each ROC curve to demonstrate the association of the predictor variable with the outcome. For demonstrative purposes, an unconventional graphic display is demonstrated, as negative predictive variables are shown as dropping below the 0.50 null line. Note the further the ROC line drifts from the 0.50 null line (either up or down), the stronger it was for predicting the outcome. Fertility and Sterility 2016 105, 1537-1546.e8DOI: (10.1016/j.fertnstert.2016.02.011) Copyright © 2016 Terms and Conditions

Figure 3 Graph demonstrating the incidence of the best embryo being good (blue), fair (red), or poor (green) for (A) cleavage embryo transfers and (B) blastocyst embryo transfers/blastocyst freezing cycles. Fertility and Sterility 2016 105, 1537-1546.e8DOI: (10.1016/j.fertnstert.2016.02.011) Copyright © 2016 Terms and Conditions

Supplemental Figure 1 Histograms demonstrating the frequency of the short and long FMR1 alleles and allele combination groups in the study population. Fertility and Sterility 2016 105, 1537-1546.e8DOI: (10.1016/j.fertnstert.2016.02.011) Copyright © 2016 Terms and Conditions

Supplemental Figure 2 Receiver operating characteristic (ROC) curves associating predictor variables with live birth. The area under the curve is shown under each ROC curve to demonstrate the association of the predictor variable with the outcome. For demonstrative purposes, an unconventional graphic display is shown such that negative predictive variables drop below the 0.50 null line. Note the further the ROC line drifts from the 0.50 null line (either up or down), the stronger it was for predicting the outcome. Fertility and Sterility 2016 105, 1537-1546.e8DOI: (10.1016/j.fertnstert.2016.02.011) Copyright © 2016 Terms and Conditions

Supplemental Figure 3 The incidence of cycle starts resulting in any blastocyst formed (blue) and a good-quality blastocyst formed (red) in the FMR1 allele groups low-low, low-normal, low-high, normal-normal, and normal-high. Error bars represent 95% confidence interval for the proportion. Fertility and Sterility 2016 105, 1537-1546.e8DOI: (10.1016/j.fertnstert.2016.02.011) Copyright © 2016 Terms and Conditions