Figure 2 Proposed mechanism of Guillain–Barré

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Figure 2 Proposed mechanism of Guillain–Barré syndrome pathogenesis mediated by Campylobacter jejuni Figure 2 | Proposed mechanism of Guillain–Barré syndrome pathogenesis mediated by Campylobacter jejuni. A molecular mimic of gangliosides in C. jejuni leads to the production of anti-ganglioside antibodies that bind to gangliosides in the axonal membrane at the node of Ranvier. Consequent activation of complement leads to disruption of voltage-gated sodium channel (NaV) clusters, disruption of the nodal architecture, and formation of the membrane attack complex, which leads to calcium influx. These changes cause axonal injury and attract macrophages, which can then migrate between the axon and myelin. Goodfellow, J. A. & Willison, H. J. (2016) Guillain–Barré syndrome: a century of progress Nat. Rev. Neurol. doi:10.1038/nrneurol.2016.172