Defensins Deisy Cifuentes Mr.Trefz Genetics.

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Presentation transcript:

Defensins Deisy Cifuentes Mr.Trefz Genetics

Amino-acid sequence They consist of 18-45 amino-acids including six (in vertebrates) to 8 conserved cyteine residues.

Structures Quaternary protein structure B-sheet structures are indicated by flat ribbons and arrows. Human neutrophil peptide 3 (HNP3, a-defensin) forms a b-sheet-rich dimer

Tetiary Protein Structure Human B-defensin 2 (HBD2) in solution is a monomer with the same general shape (defensin-fold) despite the change of the disulphide-bond pattern

Tertiary protein structure Has a B-helical segment that is linked by two disulphide bonds .

Function Defensins are active against bacteria , fungi and many enveloped and nonenveloped viruses. Cells of the immune system contain the peptides mentioned before and they kill phagocytized bacteria.

Other organism that use Defensins Vertebrates, invertebrates and plants.