BME 273: Senior Design Projects John F Gouda

Slides:



Advertisements
Similar presentations
Ernest Wollin, MD, PE, FACR Wollin Ventures Incorporated Sarasota, Florida John J. Heine, PhD Associate Professor Cancer Epidemiology Department H. Lee.
Advertisements

John Walton Fall, Grows over shallow water table areas High amount of evapotranspiration Water balance component Q out of reach = Q into.
Interface and cabling characterization for SKA Paul van der Merwe Prof. HC Reader Stellenbosch University.
Gut Motility By Dr. Aijaz. cross section of the intestinal wall layers from outer surface inward: (1) the serosa, (2) a longitudinal muscle layer, (3)
a) Parameter estimation (curve fitting)*
Electromagnetic Waves
Module 1-1 Continued Nature and Properties of Light.
Lecture 21 QCM and Ellipsometry
Lecture 7. Nuclear Magnetic Resonance (NMR). NMR is a tool that enables the user to make quantitative and structural analyses on compounds in solution.
CSTEP Cluster Sampling for Tail Estimation of Probability.
Electro-Optic Search for Threshold Divergence of the CDW Diffusion Constant in Blue Bronze (K 0.3 MoO 3 ) L. Ladino, J.W. Brill, University of Kentucky.
October 13, Dynamic System Model for Ventricular Cardiac Diastolic Function Project Proposal Justin K. Gross Project #18 University of Colorado at.
06411 Micro Nucleating Bubble Engine Team Members Steven Nathenson Joseph Pawelski Joaquin Pelaez Andrew Pionessa Brian Thomson Project Sponsors Dr. Crassidis.
Van der Pol. Convergence  The damped driven oscillator has both transient and steady-state behavior. Transient dies outTransient dies out Converges to.
Wave Nature of Light and Quantum Theory
1 Test Slide Text works. Text works. Graphics work. Graphics work.
A Spring 2005 CS 426 Senior Project By Group 15 John Studebaker, Justin Gerthoffer, David Colborne CSE Dept., University of Nevada, Reno Advisors (CSE.
Demo Guidelines Lesson 9. Modules 9.1Demo Video Guidelines 9.2Begin Filming Pitch Video 9.3Continue working on prototype.
Gastroscope Advisor: Dr. Ata Akin Design Team: Casey Gavinski Kenneth Hoyt Ashish Patel Kalpesh Trivedi.
Biological Cybernetics By: Jay Barra Sean Cain. Biological Cybernetics An interdisciplinary medium for experimental, theoretical and application- oriented.
A study of two-dimensional quantum dot helium in a magnetic field Golam Faruk * and Orion Ciftja, Department of Electrical Engineering and Department of.
Stand Alone Group Members: Jaime Alvarez Austin Chamberlain Trey Smith Jung Hoon Kim.
Introduction to Matlab and Simulink
Design of a Simulation Toolbox for Gastrointestinal Electrical Activity n BME 273: Senior Design Projects n John F Gouda n Advisor: Dr. Alan Bradshaw,
Status of the PSB impedance model C. Zannini and G. Rumolo Thanks to: E. Benedetto, N. Biancacci, E. Métral, N. Mounet, T. Rijoff, B. Salvant.
Senior Project - Electrical Engineering Coupling of Audio Signals into AFM Images Matthew Manning Advisor: Prof. Catravas Atomic force microscopy.
Surface Plasmon Resonance
Interpolation.
Cold damping of fused silica suspension violin modes V.P.Mitrofanov, K.V.Tokmakov Moscow State University G Z.
Abstract Combines are used in fields to perform the complex operations necessary to effectively harvest crops. The swath width detection system would assist.
EGR 115 Introduction to Computing for Engineers Introduction to Computer Programming Wednesday 27 Aug 2014 EGR 115 Introduction to Computing for Engineers.
Design of a Simulation Toolbox of Intestinal Electrical Activity §John Gouda §Advisor: Alan Bradshaw, Ph.D.
Non-Linear Optical Property-Structure relationship of N-(4- nitrophenyl)-N-[(1S)-1-phenylethyl]thiourea Bao Chau Tran, Tram Anh Pham, Donald Responte,
Pilhwa Lee, Ranjan Pradhan, Brian E. Carlson, Daniel A. Beard Department of Molecular and Integrative Physiology, University of Michigan-Ann Arbor Modeling.
A Non-iterative Hyperbolic, First-order Conservation Law Approach to Divergence-free Solutions to Maxwell’s Equations Richard J. Thompson 1 and Trevor.
Measurement of Electrical Signals in the Intestine Allison Redmond and Kevin Parton Advised by: Dr. Bill Richards, M.D. Dr. Alan Bradshaw, Ph.D. Dr. Scott.
JigCell Nicholas A. Allen*, Kathy C. Chen**, Emery D. Conrad**, Ranjit Randhawa*, Clifford A. Shaffer*, John J. Tyson**, Layne T. Watson* and Jason W.
Collaboration with Craig Henriquez’ laboratory at Duke University Multi-scale Electro- physiological Modeling.
Psychophysics Software Suite Yearly project for Dr. Karen Banai.
E.Sbrissa EP/TA3 - IC ATLAS EDR_MAG Magnet Project Fault analysis, QA & Failure rate.
Design of a Simulation Toolbox for Gastrointestinal Electrical Activity n BME 273: Senior Design Projects n John F Gouda n Advisor: Dr. Alan Bradshaw,
Biofeedback and Stress Management John Harrison – Leader Albert Kwansa – Communicator Eric Lee – BSAC Brenton Nelson – BWIG Dr. Daniel Muller – Client.
Fluid Starch Concentration by Volume Conclusions/Future Work
Microstructure Imaging Sequence Simulation Toolbox
Electrical Oscillator
Variation in Shoulder Elevation
GMD Research FERC Order No. 830 Research Work Plan Mark Olson, NERC
Period of Simple Harmonic Motion
Update on circuit protection simulations of the HL-LHC Inner Triplet circuit Matthias Mentink, Circuit specifics + STEAM simulations: Samer Yammine, LEDET.
Chapter 3 Simulation for BLDC Motor Drives
Demonstration of the tool
Physics-based Sound Synthesis with a Novel Friction Model
Optical Imaging of Intrinsic Cortical Signals
Axicons and Nanowires By Daniel Todd
Design Topics IC Applications Amplifier Signal Generator
Phys102 Lecture 20 Electromagnetic Waves * (skipped)
Volume 98, Issue 9, Pages (May 2010)
Marco Polo, Daniel Felinto and Sandra Vianna Departamento de Física
GMD Research FERC Order No. 830 Research Work Plan Mark Olson, NERC
05 | Desktop Applications
Objective: To know the equations of simple straight lines.
Experimental Measurement of the Induced Dipole Moment of an Isolated Molecule in Its Ground and Electronically Excited States. Indole and Indole-H2O.*
Magnetic Tweezer System Development
Volume 97, Issue 7, Pages (October 2009)
M. Kezunovic (P.I.) S. S. Luo D. Ristanovic Texas A&M University
Features of A Wave Crest and Trough Crest:
J.J Thomson.
Table 2. Modal parameters estimated by Pulse Reflex®
On behalf of the STEAM team
Objective: To know the equations of simple straight lines.
Presentation transcript:

Design of a Simulation Toolbox for Gastrointestinal Electrical Activity BME 273: Senior Design Projects John F Gouda Advisor: Dr. Alan Bradshaw, Ph.D. Assistant Professor of Physics, Living State Physics, Vanderbilt University

Motivation of Project The living state physics group have state of the art equipment to measure the magnetic field of the intestine. The magnetic field can be used to estimate the electric field: trans-membrane potential and slow currents. Thus, the need arose for an educational tool to help the investigators understand the quantitative features of electrical activity in the GI.

Further motivation After a discussion with Dr. King. The project was reorganized to serve as an educational tool for BME 251-252.

Squid

Experiment The data was collected from rabbit small intestine using platinum monopolar electrodes. 20 electrodes placed at 20 different location along the intestine 1 cm apart. Data was sampled for 5 minutes per study at a rate of 20-30 Hz. Data was sampled at the three section of the small intestine (duodenum, jejunum, ileum) and during induced ischemic conditions.

Clinical goals Study the difference between healthy electrical activity and pathologies: diabetic , ischemic electrical activity.

Design Specifications User Demands The simulation toolbox should: 1. Give the user an intuitive grasp of GI electrical activity 2. Rely on an accurate model of GI electrical activity 3. Rely on an intuitive model of GI electrical activity 4. Relate model simulations with experimental data

Project Specifications User Wishes If possible, the simulation toolbox should: 1. Have a user-friendly interface 2. Provide the user with “on the spot” calculations and metrics that represent the response of the model to the parameters supplied to the toolbox. Provide the user with a measure of goodness of fit with experimental data.

Wishes Continued 3. Provide the user with “on the spot” graphics that represent the response of the model to the parameters supplied to the toolbox 4. Provide the user with analysis modules that can analyze the complexity of GI activity and provide intuition into the physiologic function of GI tract.

Background 1960 Nelson and Becker suggest that a chain of relaxation oscillators (RO) could simulate GI electrical activity. 1971 Sarna et al. Used a modified version of the Van der Pol oscillator to simulate GI electrical activity. We used the widly acclaimed model developed by Sarna (1971).

Relaxation Oscillators The name “relaxation oscillators” comes into place because the “stress” accumulated during the slow buildup is “relaxed” during the sudden discharge.

Our model We used the widely acclaimed simple model developed by Sarna (1971). The model consists of 16 coupled nonlinear oscillators. The oscillators are lined along a straight line in the intestine.

Equations of the model 16 coupled oscillators, each oscillator has the form dxn/dt = alpha (e yn + f xn + g xn^2 + h xn^3 + C1 xn-1 + C2 xn+1) dyn/dt = -1/alpha (b yn + w^2 xn + c xn^2 + d xn^3 - a) xn= trans membrane potential yn= slow currents w= intrinsic frequency of oscillation C1 = coupling constants with previous osc. C2= coupling constant with next oscillator

Schematic

Current status of project 1. An initial prototype is up and running. 2. I am currently working on user friendly additions.

Demo Matlab

References Sarna SK, Daniel EE, Kingma YJ (1971): Simulation of slow-wave electrical activity of small intestine. Am J Physiol, 221(1):165-75.