Antibiotics.

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Presentation transcript:

Antibiotics

Antibiotics are antimicrobial agents produced by microbes Pharmaceutical companies purify the drugs and distribute it to pharmacies

Penicillin – produced by a mold Penicillium notatum. It stops the synthesis of peptidoglycan G+ usually sensitive G- resistant Selectively toxic to bacteria

Ampicillin Semisynthetic penicillin Chemical structure of penicillin is changed such that it can penetrate the outer membrane. Usually both G+ and G- are sensitive

Chloramphenicol Produced by Streptomyces Inhibits protein synthesis on the 70S ribosomes Not as selectively toxic to bacteria as penicillin. Used too long or high concentration of the drug is used, can cause aplastic anemia. Bone marrow suppression.

Streptomycin Tetracycline Erythromycin Streptomyces – inhibit protein synthesis 70S ribosomes Erythromycin cannot penetrate the outer membrane

Gentamicin Micromonospora Inhibit protein synthesis on the 70S ribosome

Sulfanilamide Competitive inhibitor Inhibits folic acid synthesis.

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