Simultaneous analysis of 1176 gene products in normal human aorta and abdominal aortic aneurysms using a membrane-based complementary DNA expression array

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Presentation transcript:

Simultaneous analysis of 1176 gene products in normal human aorta and abdominal aortic aneurysms using a membrane-based complementary DNA expression array William S. Tung, MDa, Jason K. Lee, MDa, Robert W. Thompson, MDa,b,c Journal of Vascular Surgery Volume 34, Issue 1, Pages 143-150 (July 2001) DOI: 10.1067/mva.2001.113310 Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 1 cDNA membrane arrays for AAAs and normal aorta. Representative autoradiographs are shown for membranes blotted with radiolabeled cDNA derived from an AAA and a normal aorta. Each blot is superimposed on an orientation grid corresponding to the AtlasArray Human 1.2 I membrane (Clontech), which contains bound cDNA clones from 1176 distinct gene products. Gene products represented by each location on grid are identified by accessing the manufacturer's interactive Web site, http://atlasinfo.clontech.com (follow link to AtlasInfo 2.0 and select Human 1.2 I). Journal of Vascular Surgery 2001 34, 143-150DOI: (10.1067/mva.2001.113310) Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 2 Expression of matrix proteinases and inhibitors in normal and AAAs. Representative autoradiographs are shown for portion of the AtlasArray Human 1.2 I membrane (Clontech) that contains bound cDNA clones for genes encoding extracellular matrix proteinases and their inhibitors (Sector F, Rows m and n), after blotting with radiolabeled cDNA derived from normal aorta (I ) and four different AAA specimens (I-IV ). Gene products represented by each location on membrane are identified, along with glyceraldehyde-3-phosphate dehydrogenase (GAPDH ) as housekeeping control. PAI, Plasminogen activator inhibitor; TIMP, tissue inhibitor of metalloproteinases; MMP, matrix metalloproteinase; Journal of Vascular Surgery 2001 34, 143-150DOI: (10.1067/mva.2001.113310) Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions