Aromatherapy Versus Oral Ondansetron for Antiemetic Therapy Among Adult Emergency Department Patients: A Randomized Controlled Trial Michael D. April,

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Presentation transcript:

Aromatherapy Versus Oral Ondansetron for Antiemetic Therapy Among Adult Emergency Department Patients: A Randomized Controlled Trial Michael D. April, MD, DPhil, Joshua J. Oliver, MD, William T. Davis, MD, David Ong, MD, Erica M. Simon, DO, MHA, Patrick C. Ng, MD, Curtis J. Hunter, MD Annals of Emergency Medicine Volume 72, Issue 2, Pages 184-193 (August 2018) DOI: 10.1016/j.annemergmed.2018.01.016 Copyright © 2018 American College of Emergency Physicians Terms and Conditions

Figure 1 Consolidated Standards of Reporting Trials statement diagram of patient flow. Annals of Emergency Medicine 2018 72, 184-193DOI: (10.1016/j.annemergmed.2018.01.016) Copyright © 2018 American College of Emergency Physicians Terms and Conditions

Figure 2 Nausea VAS scores at baseline and 30 minutes postintervention. Each panel represents a separate study arm including subjects allocated to inhaled isopropyl alcohol with oral ondansetron (A), inhaled isopropyl alcohol with oral placebo (B), and inhaled placebo with oral ondansetron (C). The vertical axes represent mean VAS scores (0 to 100 mm). The horizontal axes separate data for individual subjects. Each circle represents the initial VAS score for each patient, and the end of the vertical line represents the VAS at 30 minutes postintervention. The box plots on the figure margins represent summary statistics, with the central lines representing medians, boxes representing interquartile ranges, and outermost plots representing maximum and minimum nausea VAS values for the subjects composing each study arm at baseline and 30 minutes postintervention. Annals of Emergency Medicine 2018 72, 184-193DOI: (10.1016/j.annemergmed.2018.01.016) Copyright © 2018 American College of Emergency Physicians Terms and Conditions

Figure 3 Mean nausea VAS scores from study medication administration until ED disposition decision, stratified by time until ED disposition decision. Each panel presents data for subjects with different times until ED disposition, including less than 120 minutes (A), less than 180 minutes (B), and less than 240 minutes (C). The vertical axes represent mean VAS score (0 to 100 mm). The horizontal axes represent time since study treatment administration (minutes). The lines represent mean VAS for the subjects belonging to each study arm at each study interval for subjects allocated to inhaled isopropyl alcohol with oral ondansetron (solid lines), inhaled isopropyl alcohol with oral placebo (bold lines), and inhaled placebo with oral ondansetron (dashed lines). LOS, Length of stay. Annals of Emergency Medicine 2018 72, 184-193DOI: (10.1016/j.annemergmed.2018.01.016) Copyright © 2018 American College of Emergency Physicians Terms and Conditions