Ring around the Ro-sie: RNA-Mediated Alterations of PNPase Activity

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Ring around the Ro-sie: RNA-Mediated Alterations of PNPase Activity Brian J. Geiss, Jeffrey Wilusz Cell Volume 153, Issue 1, Pages 12-14 (March 2013) DOI: 10.1016/j.cell.2013.03.005 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Regulation of Protein Function by RNA Cofactors Noncoding RNAs can change the “perspective” of protein enzymes through the formation of ribonucleoprotein complexes. On the left, a PNPase (and perhaps other cellular ribonucleases) has little ability to discriminate between different types of RNA substrates. On the right, after formation of an RNP structure in which the noncoding Y RNA bridges an interaction between the Ro protein (the lens of the monocle) and PNPase, the enzyme is able to distinguish structured RNAs more clearly and is much more selective regarding the type of RNA substrate that it prefers. Cell 2013 153, 12-14DOI: (10.1016/j.cell.2013.03.005) Copyright © 2013 Elsevier Inc. Terms and Conditions