DNMT1 and Cancer: An Electrifying Link

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Presentation transcript:

DNMT1 and Cancer: An Electrifying Link Nicole N. Nuñez, Amelia H. Manlove, Sheila S. David Chemistry & Biology Volume 22, Issue 7, Pages 810-811 (July 2015) DOI: 10.1016/j.chembiol.2015.07.004 Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 1 DNA Charge Transport Based Sensor for Measuring Levels of DNA Methylation (A) The DNA “wire” is not methylated in the presence of normal cell extracts, leaving it susceptible to cleavage by the restriction enzyme (BssHII), which eliminates the electrochemical current. (B) DNA methylation by tumor cell extracts protects the DNA “wire” and maintains the electrochemical signal (represented by the lit bulb). Chemistry & Biology 2015 22, 810-811DOI: (10.1016/j.chembiol.2015.07.004) Copyright © 2015 Elsevier Ltd Terms and Conditions