Korean diet prevents obesity and ameliorates insulin resistance in mice fed a high-fat diet  Won Hee Choi, Jiyun Ahn, Chang Hwa Jung, Jung Sook Seo, Tae Youl Ha  Journal of Ethnic Foods  Volume 4, Issue 1, Pages 36-43 (March 2017) DOI: 10.1016/j.jef.2017.01.003 Copyright © 2017 Terms and Conditions

Fig. 1 Korean diet (KD) decreases body weight in a high-fat diet (HFD)-induced obese mouse model. Mice were fed the HFD for 7 weeks to induce obesity and then fed either the HFD or the KD for the next 7 weeks. The mice were weighed each week. Data are expressed as mean ± standard error of the mean (n = 10). *p < 0.05; **p < 0.01; ***p < 0.001 compared to HFD. Journal of Ethnic Foods 2017 4, 36-43DOI: (10.1016/j.jef.2017.01.003) Copyright © 2017 Terms and Conditions

Fig. 2 Korean diet (KD) decreases adiposity in a high-fat diet (HFD)-induced obese mouse model. (A) Representative micro-CT image of whole body fat (upper panel) and abdominal fat (lower panel). (B) Fat tissue weight. (C) Representative morphology and H&E images of epididymal fat tissue (original magnification, ×100). Data are expressed as mean ± SEM (n = 10). *p < 0.05; **p < 0.01 compared to HFD. H&E, hematoxylin and eosin; SEM, standard error of the mean. Journal of Ethnic Foods 2017 4, 36-43DOI: (10.1016/j.jef.2017.01.003) Copyright © 2017 Terms and Conditions

Fig. 3 Korean diet (KD) decreases hepatic lipid levels in a high-fat diet (HFD)-induced obese mouse model. (A) Liver weight, representative morphology. (B) H&E images (original magnification, ×100). (C) Hepatic lipid levels. Data are expressed as mean ± SEM (n = 10). *p < 0.05; **p < 0.01; ***p < 0.001 compared to HFD. H&E, hematoxylin and eosin; SEM, standard error of the mean. Journal of Ethnic Foods 2017 4, 36-43DOI: (10.1016/j.jef.2017.01.003) Copyright © 2017 Terms and Conditions

Fig. 4 Korean diet (KD) ameliorates insulin resistance in a high-fat diet (HFD)-induced obese mouse model. (A, B) Glucose clearance was assessed by the oral glucose tolerance test (OGTT, 2 g/kg). (C) Pancreatic islet morphology and insulin were assessed by immunohistochemistry (original magnification, ×100). Data are expressed as mean ± SEM (n = 10). *p < 0.05; ***p < 0.001 compared to HFD. SEM, standard error of the mean. Journal of Ethnic Foods 2017 4, 36-43DOI: (10.1016/j.jef.2017.01.003) Copyright © 2017 Terms and Conditions

Fig. 5 Korean diet (KD) regulates the expression of lipid and glucose metabolism-related genes in a high-fat diet (HFD)-induced obese mouse model. Relative mRNA levels were determined by qRT-PCR, and target mRNA levels were normalized to GAPDH mRNA level. Data are expressed as mean ± SEM (n = 10). **p < 0.01; ***p < 0.001 compared to HFD. ACSL, acyl-COA synthetase; FAS, fatty acid synthase; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; GK, glucokinase; qRT-PCR, quantitative reverse transcription-polymerase chain reaction; SCD1, stearoyl-CoA desaturase-1; SEM, standard error of the mean. Journal of Ethnic Foods 2017 4, 36-43DOI: (10.1016/j.jef.2017.01.003) Copyright © 2017 Terms and Conditions