Genomic Alterations in Biliary Tract Cancer Using Targeted Sequencing

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Genomic Alterations in Biliary Tract Cancer Using Targeted Sequencing Kwai Han Yoo, Nayoung K.D. Kim, Woo Il Kwon, Chung Lee, Sun Young Kim, Jiryeon Jang, Jungmi Ahn, Mihyun Kang, Hyojin Jang, Seung Tae Kim, Soomin Ahn, Kee-Taek Jang, Young Suk Park, Woong-Yang Park, Jeeyun Lee, Jin Seok Heo, Joon Oh Park Translational Oncology Volume 9, Issue 3, Pages 173-178 (June 2016) DOI: 10.1016/j.tranon.2016.01.007 Copyright © 2015 Terms and Conditions

Figure 1 Genomic landscape of 19 BTC patients. Hilar CCC, hilar cholangiocarcinoma; IC CCC, intrahepatic cholangiocarcinoma; dCBD, distal common bile duct cancer; GB ADC, gallbladder adenocarcinoma; GB NEC, gallbladder neuroendocrine carcinoma; AoV, ampulla of Vater; FFPE, formalin-fixed paraffin-embedded; Amp*, amplification; Del†, deletion. Translational Oncology 2016 9, 173-178DOI: (10.1016/j.tranon.2016.01.007) Copyright © 2015 Terms and Conditions

Figure 2 (A) Immunohistochemistry staining and (B) fluorescence in situ hybridization of HER2 in a patient with ampulla of Vater cancer (case 19 in Figure 1) (400× magnification). Translational Oncology 2016 9, 173-178DOI: (10.1016/j.tranon.2016.01.007) Copyright © 2015 Terms and Conditions

Figure 3 Immunohistochemical correlation between primary tumors and PDCs. (A) Primary cholangiocarcinoma (adenocarcinoma) (upper panel) and PDCs derived from malignant ascites (lower panel); (B) primary cholangiocarcinoma (adenocarcinoma) (upper panel) and PDCs derived from malignant pleural effusion (lower panel); (C) primary cholangiocarcinoma (adenocarcinoma) (upper panel) and PDCs derived from malignant ascites (lower panel). *Left and right sides represent immunohistochemical staining of CK7 and CK20, respectively (400× magnification). Translational Oncology 2016 9, 173-178DOI: (10.1016/j.tranon.2016.01.007) Copyright © 2015 Terms and Conditions