Steady-State Kinetics and Dynamics of Morphine in Cancer Patients

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Presentation transcript:

Steady-State Kinetics and Dynamics of Morphine in Cancer Patients Lona L Christrup, PhD, Per Sjøgren, MD, Niels-Henrik Jensen, MD, Anne-Marie Banning, MD, Karsten Elbæk, MSc, Annette K Ersbøll, PhD Journal of Pain and Symptom Management Volume 18, Issue 3, Pages 164-173 (September 1999) DOI: 10.1016/S0885-3924(99)00068-8

Fig. 1 The mean individual pain VAS (PVAS) scores as a function of mean individual M6G + MOR plasma concentrations following administration of IR (1a) and CR (1b) tablet Journal of Pain and Symptom Management 1999 18, 164-173DOI: (10.1016/S0885-3924(99)00068-8)

Fig. 2 The mean individual pain VAS (PVAS) scores as a function of mean individual M6G:MOR plasma concentrations following administration of IR (2a) and CR (2b) tablet Journal of Pain and Symptom Management 1999 18, 164-173DOI: (10.1016/S0885-3924(99)00068-8)

Fig. 3 The mean normalized morphine plasma concentrations (CONC), pain VAS (PVAS), and sedation VAS (SVAS) scores as a function of time following administration of IR (1a) and CR (1b) tablet Journal of Pain and Symptom Management 1999 18, 164-173DOI: (10.1016/S0885-3924(99)00068-8)