A Comparison of the Pharmacokinetics, Clinical Efficacy, and Tolerability of Once-Daily Tramadol Tablets with Normal Release Tramadol Capsules Bhavesh.

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Presentation transcript:

A Comparison of the Pharmacokinetics, Clinical Efficacy, and Tolerability of Once-Daily Tramadol Tablets with Normal Release Tramadol Capsules Bhavesh Bodalia, MB ChB, DRCOG, Chris J McDonald, MB BS, MRCOphth, FFPM, Kevin J Smith, BSc (Hons), PhD, Catherine O'Brien, BSc (Hons), Lois Cousens, BSc (Hons) Journal of Pain and Symptom Management Volume 25, Issue 2, Pages 142-149 (February 2003) DOI: 10.1016/S0885-3924(02)00642-5

Fig. 1 Plasma tramadol and O-desmethyltramadol profiles at steady-state for volunteers receiving OD tablet 150 mg (triangle), OD tablet 200 mg (square), or NR capsule 50 mg (bar). Journal of Pain and Symptom Management 2003 25, 142-149DOI: (10.1016/S0885-3924(02)00642-5)

Fig. 2 Disposition of patients enrolled in the clinical study. A = OD tablet 150 mg, B = OD tablet 200 mg, and C = NR capsule 50 mg. Journal of Pain and Symptom Management 2003 25, 142-149DOI: (10.1016/S0885-3924(02)00642-5)

Fig. 3 Adjusted mean treatment differences in VAS pain scores (95% confidence intervals). A = OD tablet 150 mg, B = OD tablet 200 mg, and C = NR capsule 50 mg. Journal of Pain and Symptom Management 2003 25, 142-149DOI: (10.1016/S0885-3924(02)00642-5)