Sachiko Matsuzaki, M. D. , Takashi Murakami, M. D. , Shigeki Uehara, M

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Expression of estrogen receptor alpha and beta in peritoneal and ovarian endometriosis Sachiko Matsuzaki, M.D., Takashi Murakami, M.D., Shigeki Uehara, M.D., Michel Canis, M.D., Hironobu Sasano, M.D., Kunihiro Okamura, M.D. Fertility and Sterility Volume 75, Issue 6, Pages 1198-1205 (June 2001) DOI: 10.1016/S0015-0282(01)01783-6

Figure 1 ER-α:ER-β mRNA ratios in the eutopic endometrium and endometriotic tissues. Values represent type of samples and their conditions: 1, eutopic endometrium (P: n = 12, S: n = 12); 2, ovarian endometriotic lesions (P: n = 9, S: n = 11); 3, red peritoneal lesions (P: n = 6, S: n = 6); and 4, black peritoneal lesions (P: n = 6, S: n = 6). The horizontal lines represent median value. P = proliferative phase; S = secretory phase. ∗Significantly different from the values observed in secretory endometrium (P<.001). ∗∗Significantly different from the values observed in ovarian endometriotic lesions and black peritoneal lesions during the proliferative phase (P<.04 and P<.01, respectively). ∗∗∗Significantly different from the values observed in ovarian endometriotic lesions and black peritoneal lesions during the secretory phase (P<.05 and P<.01, respectively). Matsuzaki. Estrogen receptors α and β in endometriosis. Fertil Steril 2001. Fertility and Sterility 2001 75, 1198-1205DOI: (10.1016/S0015-0282(01)01783-6)

Figure 2 In situ localization of ER-α and ER-β mRNA in peritoneal and ovarian endometriosis. ISH was performed on adjacent sections with an antisense probe to ER-α (A, C, E) and an antisense probe to ER-β (B, D, F). Red peritoneal lesion (A, B): ER-α hybridization signals, appearing red as a result of fast-red staining, were detected in glandular epithelial and stromal cels. No ER-β hybridization signals were detected. Black peritoneal lesion (C, D): both ER-α and ER-β mRNA hybridization signals, appearing red as a result of fast-red staining, were detected in stromal cells. Ovarian endometriotic cyst (E, F): ER-α hybridization signals, appearing red as a result of fast-red staining, were detected in glandular epithelial and stromal cells. No ER-β hybridization signals were detected. For all parts, bar = 50 μm. Matsuzaki. Estrogen receptors α and β in endometriosis. Fertil Steril 2001. Fertility and Sterility 2001 75, 1198-1205DOI: (10.1016/S0015-0282(01)01783-6)