Nerve conduction block in diabetic rats using high-intensity focused ultrasound for analgesic applications Y-F. Lee, C-C. Lin, J-S. Cheng, G-S. Chen

Slides:

Advertisements

Similar presentations

Application of Ultrasound and Ultrasound-Guided Intervention for Evaluating Elbow Joint Pathologies Chia-Wei Lin, Yan-Hao Chen, Wen-Shiang Chen Journal.

Advertisements

Peter W. Henderson, MD, George K

Electroacupuncture inhibits excessive interferon-γ evoked up-regulation of P2X4 receptor in spinal microglia in a CCI rat model for neuropathic pain

Erector spinae plane block for pain relief in rib fractures

Randomized controlled trial comparing the McGrath videolaryngoscope with the C-MAC videolaryngoscope in intubating adult patients with potential difficult.

X. Sala Blanch, A. M. López, J. Carazo, A. Hadzic, A. Carrera, J

D Latzke, P Marhofer, M Zeitlinger, A Machata, F Neumann, E Lackner, S

Addition of transversus thoracic muscle plane block to pectoral nerves block provides more effective perioperative pain relief than pectoral nerves block.

Z. Y. Yu, J. Geng, Z. Q. Li, Y. B. Sun, S. L. Wang, J. Masters, D. X

X. Sun, J. Ellis, P.J. Corso, P.C. Hill, F. Chen, J. Lindsay

Type of anaesthesia and patient quality of recovery: a randomized trial comparing propofol–remifentanil total i.v. anaesthesia with desflurane anaesthesia

J.-A. Lin, H.-T. Lu British Journal of Anaesthesia

Fifteen years of ultrasound guidance in regional anaesthesia: Part 1

Lidocaine use in ultrasound-guided femoral nerve block: what is the minimum effective anaesthetic concentration (MEAC90)?† A.M. Taha, A.M. Abd-Elmaksoud

Analgesic efficacy of ultrasound-guided transversus abdominis plane block in patients undergoing open appendicectomy† G. Niraj, A. Searle, M. Mathews,

P. Cuvillon, V. Reubrecht, L. Zoric, L. Lemoine, M. Belin, O

Sevoflurane promotes the expansion of glioma stem cells through activation of hypoxia- inducible factors in vitro Q.Y. Shi, S.J. Zhang, L. Liu, Q.S. Chen,

J.-A. Lin, H.-T. Lu British Journal of Anaesthesia

The use of high-intensity focused ultrasound as a novel treatment for painful conditions—a description and narrative review of the literature M.R.D.

Triaging the right patient to the right place in the shortest time

A different use of visual analytic techniques in anaesthetics

Retrospective analysis of the incidence of epidural haematoma in patients with epidural catheters and abnormal coagulation parameters P. Gulur, B. Tsui,

Neuraxial anaesthesia in patients with scoliosis

Comparative evaluation of the visibility and block characteristics of a stimulating needle and catheter vs an echogenic needle and catheter for sciatic.

Ultrasound-guided anterior sciatic nerve block in the proximal thigh: an in-plane approach improving the needle view and respecting fascial planes J.

Single sevoflurane exposure decreases neuronal nitric oxide synthase levels in the hippocampus of developing rats X. Feng, J.J. Liu, X. Zhou, F.H. Song,

K.P. Mason British Journal of Anaesthesia

Anticipating guidelines for ultrasound-guided arterial catheterization

L. -C. Chu, M. -L. Tsaur, C. -S. Lin, Y. -C. Hung, T. -Y. Wang, C. -C

C. Cozowicz, J. Poeran, S.G. Memtsoudis British Journal of Anaesthesia

Diabetic neuropathy increases stimulation threshold during popliteal sciatic nerve block† S Heschl, B Hallmann, T Zilke, G Gemes, M Schoerghuber, M.

Complications of peripheral nerve blocks

Ultrasound-guided percutaneous cryoneurolysis for treatment of acute pain: could cryoanalgesia replace continuous peripheral nerve blocks? B.M. Ilfeld,

Does regional anaesthesia improve outcome?

K.J. Chin British Journal of Anaesthesia

Comparison of motor-evoked potentials monitoring in response to transcranial electrical stimulation in subjects undergoing neurosurgery with partial vs.

Sonographic visualization and ultrasound-guided blockade of the greater occipital nerve: a comparison of two selective techniques confirmed by anatomical.

Sevoflurane post-conditioning increases nuclear factor erythroid 2-related factor and haemoxygenase-1 expression via protein kinase C pathway in a rat.

Ultrasound standard for lumbar plexus block

Effects of early and late diabetic neuropathy on sciatic nerve block duration and neurotoxicity in Zucker diabetic fatty rats P. Lirk, C. Verhamme, R.

Isotonic crystalloid solutions: a structured review of the literature

Y.H. Hsu, H.T. Hsu, K.I. Cheng British Journal of Anaesthesia

Ultrasound-guided central venous catheterization in the prone position

Effects of ultrasound guidance on the minimum effective anaesthetic volume required to block the femoral nerve A. Casati, M. Baciarello, S. Di Cianni,

Visual metaphors on anaesthesia monitors do not improve anaesthetists' performance in the operating theatre K. van Amsterdam, F. Cnossen, A. Ballast,

Efficacy of ventilation through a customized novel cuffed airway exchange catheter: a tracheal/lung model study J. Oto, M.Q. Sun, R.M. Kacmarek, Y. Jiang

L1–2 roots block with psoas compartment block?

C. Price, J. Lee, A.M. Taylor, A.P. Baranowski

Ultrasound-guided popliteal sciatic nerve block using a pocket-sized ultrasound machine: preliminary evidence T. Saranteas, F. Zafiropoulou, G. Kostopanagiotou,

Effects of different remifentanil target concentrations on MAC BAR of sevoflurane in gynaecological patients with CO2 pneumoperitoneum stimulus Z.-Y.

Experimental behaviour testing: pain

The third ultrasound dimension in anaesthesia and intensive care

Is sickle cell disease a possible risk factor for peripheral neuropathy after popliteal sciatic nerve block? M Giabicani, V Compère, V Fourdrinier, B.

J.B. Barbary, F. Remérand, J. Brilhault, M. Laffon, J. Fusciardi

New insights into the pathophysiology of aspiration pneumonia

J Lee, S Gupta, C Price, A.P. Baranowski

Pulmonary blood volume measured by contrast enhanced ultrasound: a comparison with transpulmonary thermodilution I.H.F. Herold, M.A. Soliman Hamad, H.C.

Chronic widespread pain, including fibromyalgia: a pathway for care developed by the British Pain Society J. Lee, B. Ellis, C. Price, A.P. Baranowski

Effect of early tracheostomy on resource utilization and clinical outcomes in critically ill patients: meta-analysis of randomized controlled trials

Ventilation with the Ventrain through a small lumen catheter in the failed paediatric airway: two case reports M.G.A. Willemsen, R. Noppens, A.L.M. Mulder,

G. Lockwood British Journal of Anaesthesia

R Hofmeyr, A Myburgh British Journal of Anaesthesia

T. Greco, M. G. Calabrò, R. D. Covello, M. Greco, L. Pasin, A

Cut tracheal tube and GlideRite® Rigid Stylet

ICU fire evacuation preparedness in London: a cross-sectional study

Discriminant analysis for anaesthetic decision-making: an intelligent recognition system for epidural needle insertion S.P. Lin, M.S. Mandell, Y. Chang,

Regional anaesthesia to improve pain outcomes in paediatric surgical patients: a qualitative systematic review of randomized controlled trials S. Suresh,

C.M. Chalmers, A.M. Bal British Journal of Anaesthesia

Effect of concentration of local anaesthetic solution on the ED50 of bupivacaine for supraclavicular brachial plexus block† P.K. Gupta, P.M. Hopkins

Real-time ultrasound-guided epidural anaesthesia technique can be improved by new echogenic Tuohy needles: a pilot study in cadavers C. Menacé, O. Choquet,

Presentation transcript:

Nerve conduction block in diabetic rats using high-intensity focused ultrasound for analgesic applications Y-F. Lee, C-C. Lin, J-S. Cheng, G-S. Chen British Journal of Anaesthesia Volume 114, Issue 5, Pages 840-846 (May 2015) DOI: 10.1093/bja/aeu443 Copyright © 2015 The Author(s) Terms and Conditions

Fig 1 The experimental configuration used for in vitro nerve treatment with high-intensity focused ultrasound (HIFU). The sciatic notch was placed in the central chamber of the nerve platform and sonicated using top-down HIFU. A needle thermocouple was used to monitor the temperature of the Ringer solution in the central chamber. CAPs, compound action potentials; SAPs, sensory action potentials. British Journal of Anaesthesia 2015 114, 840-846DOI: (10.1093/bja/aeu443) Copyright © 2015 The Author(s) Terms and Conditions

Fig 2 The temporal courses of the CAP and SAP peaks after HIFU exposure of nerves from control (a) and diabetic rats (b) in vitro. The incident HIFU parameters for the control and diabetic nerves were 2290 W cm−2 for 4 s and 1850 W cm−2 for 4 s, respectively. Median values and ranges are shown (n=12). British Journal of Anaesthesia 2015 114, 840-846DOI: (10.1093/bja/aeu443) Copyright © 2015 The Author(s) Terms and Conditions

Fig 3 The temporal courses for days 1 (a), 7 (b), 14 (b), and 28 (b) of the compound muscle action potential (CMAP) peaks of control rat nerves in vivo after an HIFU exposure of 2290 W cm−2 for 7 s (diamonds), 12 s (squares), and 18 s (triangles). n=6 for each HIFU parameter. *Significantly different from day 1. British Journal of Anaesthesia 2015 114, 840-846DOI: (10.1093/bja/aeu443) Copyright © 2015 The Author(s) Terms and Conditions

Fig 4 The temporal courses for days 1 (a), 7 (b), 14 (b), and 28 (b) of the CMAP peaks of diabetic rat nerves in vivo after an HIFU exposure of 2810 W cm−2 for 3 (diamonds), 5 (squares), and 8 s (triangles). n=6 for each HIFU parameter. *Significantly different from day 1. British Journal of Anaesthesia 2015 114, 840-846DOI: (10.1093/bja/aeu443) Copyright © 2015 The Author(s) Terms and Conditions

Fig 5 Photomicrographs of haematoxylin- and eosin-stained sections of a representative control rat sciatic nerve on day 1 after HIFU (2290 W cm−2 for 7 s; a) and on day 28 after HIFU (2290 W cm−2 for 18 s; b). (c) A diabetic rat nerve on day 1 after HIFU (2810 W cm−2 for 3 s). (d), (e), and (f) Enlarged images (×400) of a local region of (a), (b), and (c). British Journal of Anaesthesia 2015 114, 840-846DOI: (10.1093/bja/aeu443) Copyright © 2015 The Author(s) Terms and Conditions