Margaretha A. Faber, MD, PhD, Athina L. Van Gasse, MD, Ine I

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Presentation transcript:

IgE-reactivity profiles to nonspecific lipid transfer proteins in a northwestern European country Margaretha A. Faber, MD, PhD, Athina L. Van Gasse, MD, Ine I. Decuyper, MD, Astrid Uyttebroek, MD, Vito Sabato, MD, PhD, Margo M. Hagendorens, MD, PhD, Chris H. Bridts, MLT, Luc S. De Clerck, MD, PhD, Montserrat Fernandez-Rivas, MD, PhD, Mariona Pascal, PhD, Araceli Diaz-Perales, PhD, Didier G. Ebo, MD, PhD Journal of Allergy and Clinical Immunology Volume 139, Issue 2, Pages 679-682.e5 (February 2017) DOI: 10.1016/j.jaci.2016.06.016 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Dendrogram and heat map of total IgE and specific IgE results to rPru p 3, rMal d 3, rAra h 9, rCor a 8, nArt v 3, and rPar j 2. In the first column, clinical symptoms of the patients (pollen allergic, plant food allergic, pollen and plant food allergic) are displayed. Journal of Allergy and Clinical Immunology 2017 139, 679-682.e5DOI: (10.1016/j.jaci.2016.06.016) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 A, Food-specific clinical manifestations for peach in Pru p 3+ patients, apple in Mal d 3+ patients, peanut in Ara h 9+ patients, and hazelnut in Cor a 8+ patients. Frequencies were displayed with 95% CI. B, Specific IgE to rPru p 3 in 38 individuals in whom a BAT with rPru p 3 was performed; healthy control individuals (HC, n = 8), patients with pollinosis (n = 11), patients allergic to peach experiencing generalized reactions (GR, n = 4) or OAS (n = 7), and patients tolerating peach (TOL, n = 8) but showing specific IgE reactivity to Pru p 3. C, Results of BAT with 1 μg/mL rPru p 3 expressed as net percentage of CD63 upregulation in the same groups as described above. GR, Generalized reaction and unknown; TOL, tolerating the indicated food. Journal of Allergy and Clinical Immunology 2017 139, 679-682.e5DOI: (10.1016/j.jaci.2016.06.016) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Overview of the study group stratified according to clinical symptoms on exposure to pollen and/or plant food with a subdivision based on specific IgE reactivity to at least 1 of the 6 evaluated ns-LTPs (nArt v 3, rAra h 9, rCor a 8, rMal d 3, rPar j 2, and rPru p 3). Patients were further stratified according to age (preschool children, 0-6 years; school children, 7-18 years; and adults, >18 years). Frequencies (%) were displayed including 95% CI. *Specific IgE reactivity to ns-LTPs was more frequent in children at preschool with only plant food allergy as compared with the other 2 clinical phenotypes (χ2; P < .05). Journal of Allergy and Clinical Immunology 2017 139, 679-682.e5DOI: (10.1016/j.jaci.2016.06.016) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Graphical representation of the correlation of total IgE (tIgE) with specific IgE to rPru p 3 (A), rMal d 3 (B), rAra h 9 (C), rCor a 8 (D), nArt v 3 (E), and rPar j 2 (F). Spearman ranking coefficients (r) are displayed in the right upper corner of each graph. Journal of Allergy and Clinical Immunology 2017 139, 679-682.e5DOI: (10.1016/j.jaci.2016.06.016) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Specific IgE to rPru p 3, rMal d 3, rAra h 9, nArt v 3, rCor a 8, and rPar j 2 in patients with pollen allergic symptoms (green), plant food allergic symptoms (blue), and pollen and plant food allergic symptoms (red). Levels less than 0.10 kUa/L (or negative) were set to 0.01 kUa/L. Journal of Allergy and Clinical Immunology 2017 139, 679-682.e5DOI: (10.1016/j.jaci.2016.06.016) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Graphical representation of the correlation of specific IgE to rMal d 3 (A), rAra h 9 (B), rCor a 8 (C), nArt v 3 (D), and rPar j 2 (E) with rPru p 3. Spearman correlation coefficients are displayed in the right corner of the different figures. The number of patients with double-negative specific IgE results is displayed in the bottom left corner of each figure. Journal of Allergy and Clinical Immunology 2017 139, 679-682.e5DOI: (10.1016/j.jaci.2016.06.016) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions