Volume 139, Issue 6, Pages e2 (December 2010)

Slides:

Advertisements

Similar presentations

Irritable Bowel Syndrome and Microscopic Colitis: A Systematic Review and Meta- analysis Eline J.C.A. Kamp, John S. Kane, Alexander C. Ford Clinical Gastroenterology.

Advertisements

American Gastroenterological Association Institute Technical Review on the Management of Acute Diverticulitis Lisa L. Strate, Anne F. Peery, Ignacio.

Psyllium Fiber Reduces Abdominal Pain in Children With Irritable Bowel Syndrome in a Randomized, Double-Blind Trial Robert J. Shulman, Emily B. Hollister,

The Value of a 24/7 Online Nationwide Multidisciplinary Expert Panel for Acute Necrotizing Pancreatitis Janneke van Grinsven, Sandra van Brunschot Gastroenterology

Effect of Linaclotide on Severe Abdominal Symptoms in Patients With Irritable Bowel Syndrome With Constipation Satish S.C. Rao, Eamonn M.M. Quigley,

Jiann–Hwa Chen, Chung–Tai Yue, Chieh–Wen Lai Gastroenterology

Hirschsprung's Disease With Impending Abdominal Compartment Syndrome

Effect of Linaclotide on Severe Abdominal Symptoms in Patients With Irritable Bowel Syndrome With Constipation Satish S.C. Rao, Eamonn M.M. Quigley,

Volume 150, Issue 2, Pages e8 (February 2016)

Safety and Efficacy of Teduglutide After 52 Weeks of Treatment in Patients With Short Bowel Intestinal Failure Stephen J.D. O'Keefe, Palle B. Jeppesen,

Charles D. Gerson, Mary-Joan Gerson

Volume 133, Issue 2, Pages (August 2007)

Christoph Lübbert, Babett Holler Gastroenterology

Covering the Cover Gastroenterology

The Value of a 24/7 Online Nationwide Multidisciplinary Expert Panel for Acute Necrotizing Pancreatitis Janneke van Grinsven, Sandra van Brunschot Gastroenterology

Efficacy of a Chinese Herbal Medicine in Providing Adequate Relief of Constipation- predominant Irritable Bowel Syndrome: A Randomized Controlled Trial

Factors Associated With Response to Placebo in Patients With Irritable Bowel Syndrome and Constipation Sarah Ballou, Alissa Beath, Ted J. Kaptchuk, William.

Volume 145, Issue 6, Pages e1 (December 2013)

Safety and Efficacy of Teduglutide After 52 Weeks of Treatment in Patients With Short Bowel Intestinal Failure Stephen J.D. O'Keefe, Palle B. Jeppesen,

Volume 133, Issue 5, Pages (November 2007)

A Patient With Left Upper Abdominal Pain Who Had Petit Sac

Prevalence of Irritable Bowel Syndrome–type Symptoms in Patients With Celiac Disease: A Meta-analysis Anita Sainsbury, David S. Sanders, Alexander C.

Hirschsprung's Disease With Impending Abdominal Compartment Syndrome

Volume 147, Issue 6, Pages e1 (December 2014)

Volatile Organic Compounds in Feces Associate With Response to Dietary Intervention in Patients With Irritable Bowel Syndrome Megan Rossi, Raphael Aggio,

Volume 145, Issue 2, Pages e1 (August 2013)

Volume 154, Issue 4, Pages e1 (March 2018)

Unusual Case of an Upset Stomach

Sang Pyo Lee, Hang Lak Lee, Kang Nyeong Lee Gastroenterology

Volume 150, Issue 4, Pages (April 2016)

Effect of Ramosetron on Stool Consistency in Male Patients With Irritable Bowel Syndrome With Diarrhea Shin Fukudo, Motoko Ida, Hiraku Akiho, Yoshihiro.

American Gastroenterological Association Institute Technical Review on the Management of Acute Diverticulitis Lisa L. Strate, Anne F. Peery, Ignacio.

Volume 133, Issue 2, Pages (August 2007)

Volume 155, Issue 5, Pages e2 (November 2018)

Abdominal Pain in a Patient 13 Years After Roux-en-Y Gastric Bypass

A Rare Cause of Postprandial Abdominal Pain and Nausea

Jiann–Hwa Chen, Chung–Tai Yue, Chieh–Wen Lai Gastroenterology

Brian M. Fung, Nora Ostrzega, James H. Tabibian Gastroenterology

Psyllium Fiber Reduces Abdominal Pain in Children With Irritable Bowel Syndrome in a Randomized, Double-Blind Trial Robert J. Shulman, Emily B. Hollister,

Volume 150, Issue 2, Pages e8 (February 2016)

Volume 151, Issue 6, Pages (December 2016)

Eluxadoline Demonstrates a Lack of Abuse Potential in Phase 2 and 3 Studies of Patients With Irritable Bowel Syndrome With Diarrhea Reginald V. Fant,

Effects of 5-Hydroxytryptamine (Serotonin) Type 3 Antagonists on Symptom Relief and Constipation in Nonconstipated Irritable Bowel Syndrome: A Systematic.

Effects of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation or Chronic Constipation: A Meta-analysis Elizabeth J. Videlock, Vivian.

Volume 151, Issue 1, Pages e6 (July 2016)

Laura Rotundo, Sushil Ahlawat Gastroenterology

Efficacy of Linaclotide for Patients With Chronic Constipation

Acute Abdominal Pain in a Teenager With Anorexia Nervosa

Volume 153, Issue 4, Pages (October 2017)

Rebecca M. Lovell, Alexander C. Ford

Effects of Different Coping Strategies on Physical and Mental Health of Patients With Irritable Bowel Syndrome Lilian Dindo, PhD Clinical Gastroenterology.

Benjamin Kloesel, Vishal S. Chandan, Glenn L. Alexander

Volume 140, Issue 6, Pages e2 (May 2011)

Volume 153, Issue 5, Pages e2 (November 2017)

Jikyoung Lee, Jong Jin Hyun, Hong Sik Lee Gastroenterology

The Dawning of a New Editorial Board for Gastroenterology

An Elderly Woman With Upper Abdominal Pain and a 60-Pound Weight Loss

Secondary Prophylaxis of Hepatic Encephalopathy: An Open-Label Randomized Controlled Trial of Lactulose Versus Placebo Barjesh Chander Sharma, Praveen.

A 27-Year-Old Woman With Constipation: Diagnosis and Treatment

Pao-Ying Lin, Horng-Yuan Lou, Chun-Chao Chang Gastroenterology

Volume 155, Issue 6, Pages (December 2018)

Volume 139, Issue 6, Pages e1 (December 2010)

Unusual Cause of Abdominal Pain After Laparoscopic Cholecystectomy

A Palpable Mass in a Young Man With Chronic Lower Abdominal Pain

Effect of Ramosetron on Stool Consistency in Male Patients With Irritable Bowel Syndrome With Diarrhea Shin Fukudo, Motoko Ida, Hiraku Akiho, Yoshihiro.

Electronic Clinical Challenges and Images in GI

Volume 139, Issue 6, Pages e2 (December 2010)

A Female Patient With Persistent Epigastric Pain for 1 Week

Self-Administered Cognitive Behavior Therapy for Moderate to Severe Irritable Bowel Syndrome: Clinical Efficacy, Tolerability, Feasibility Jeffrey M.

Unrelenting Abdominal Pain after Recent Initiation of a Direct Oral Anticoagulant: A Cause for Concern Nicholas R. Crews, Nabil Fayad Gastroenterology

Presentation transcript:

Volume 139, Issue 6, Pages 1877-1886.e2 (December 2010) Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation Jeffrey M. Johnston, Caroline B. Kurtz, James E. MacDougall, Bernard J. Lavins, Mark G. Currie, Donald A. Fitch, Chris O'Dea, Mollie Baird, Anthony J. Lembo Gastroenterology Volume 139, Issue 6, Pages 1877-1886.e2 (December 2010) DOI: 10.1053/j.gastro.2010.08.041 Copyright © 2010 AGA Institute Terms and Conditions

Figure 1 Weekly mean change from baseline in CSBM rate (A) and abdominal pain (B) for linaclotide 75, 150, 300, and 600 μg and placebo. Gastroenterology 2010 139, 1877-1886.e2DOI: (10.1053/j.gastro.2010.08.041) Copyright © 2010 AGA Institute Terms and Conditions

Figure 2 Mean abdominal pain (A), abdominal pain in “severe” patients (B), abdominal discomfort (C), and bloating (D) ratings during the 2-week pretreatment baseline and 12-week treatment periods for linaclotide 75, 150, 300, and 600 μg and placebo. Gastroenterology 2010 139, 1877-1886.e2DOI: (10.1053/j.gastro.2010.08.041) Copyright © 2010 AGA Institute Terms and Conditions

Figure 3 Percentage of patients who were (A) adequate relief responders during the 12-week treatment periods and (B) global relief responders during the 12-week treatment period for linaclotide 75, 150, 300, and 600 μg and placebo. Gastroenterology 2010 139, 1877-1886.e2DOI: (10.1053/j.gastro.2010.08.041) Copyright © 2010 AGA Institute Terms and Conditions

Supplementary Figure 1 Diagram of patient flow. Gastroenterology 2010 139, 1877-1886.e2DOI: (10.1053/j.gastro.2010.08.041) Copyright © 2010 AGA Institute Terms and Conditions