Chair and Discussant: Karla Hemming University of Birmingham Recent Developments in the Design and Analysis of Cluster Randomized Controlled Trials Society of Clinical Trials and International Methodology Conference May 9th 2017 Introduction to me.. Thanks so much for the invitation. Love study design, particularly experimental design Background and lots of training at LSHTM Will give a little introduction to my academic home Am asst prof of Biostatistics and Global Health Chair and Discussant: Karla Hemming University of Birmingham

Session Summary

CRT Design and Analysis Talk 1 Talk 2 Talk 3

Talk 1 – Developments in Design (Liz) Design Challenges – Focus: Parallel-Arm Clustering Change in individuals or in populations Baseline imbalance: Cluster Size & Covariates Power and Sample Size Alternatives to the Parallel-Arm CRT Crossover CRT Stepped Wedge CRT Pseudo-Cluster Trial Individually-Randomized Group Treatment Trial

Talk 2 – Linking Design to Analysis (Fan) Focus: baseline covariate balance Design-based strategies Matching Stratification Covariate-Constrained Randomization Analysis-based strategies Match analysis to the design

Talk 3 – Developments in Analysis (Melanie) Focus: Population-averaged effects Considerable developments in past 10 yrs Statistical Methods GEE Alternatives to GEE QIF (quadratic inference function) tMLE (targeted maximum likelihood) Augmented GEE

Any questions or comments? Online first - American Journal of Public Health Any questions or comments?