Figure 11.1 Model of the active site of mammalian CYP2C5 showing the protoporphyrin IX prosthetic group (red) with the cysteine thiolate ligand (yellow)

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Figure 11.1 Model of the active site of mammalian CYP2C5 showing the protoporphyrin IX prosthetic group (red) with the cysteine thiolate ligand (yellow) attached to the heme iron. Generated from Protein Data Bank file 1NR6, deposited by M. R. Wester, E. F. Johnson, and C. D. Stout, using WebLab Viewer Lite (Molecular Simulations, Inc.).. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 11.2 The absorvance spectrum of the carbon monoxide-bound cytochrome P450. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 11.3 Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 11.4 Ribbon diagram of human cytochrome P450 reductase based on its crystal structure. The figure was rendered using the program Molscript (Kraulis, P. J. Molscript: A program to produce both detailed and schematic plots of protein structures. J. Appl. Cryst. 24:946, 1991). Generously supplied by Dr. Jung-Ja P. Kim, Professor of Biochemistry, Medical College of Wisconsin, before publication. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 11.5 Components of the endoplamic reticulum (microsomal) cytochrome P450 system. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 11.6 Reaction cycle of cytochrome p450. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 11.7 Components of mitochondrial cytochrome P450 system. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 11.8 Common reactions catalyzed by cytochromes P450. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 11.9 Steroid hormone synthesis in the adrenal gland. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 11.10 Side-chain cleavage reaction of cholesterol. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 11.11 The sequence of reactions leading to the aromatization of androgens to estrogens. Adapted from Graham-Lorence, S., Amarneh, B., White R. E., Peterson, J. A., and Simpson E. R., A three dimensional model of aromatase cytochrome P450. Protein Science 4: 1065, 1995. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 11.12 The metabolism of diazepam by CYPs 3A4 and 2C19. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 11.13 The metabolism of terfenadine to fexofenadine, the bioactive compound. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 11.14 Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 11.15 Acetaminophen may be metabolized by the phase II enzymes sulfotransferase and glucuronsyl transferase and by CUP2E1. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 11.16 The interaction of a ligand with its receptor and receptor partner to form the heterodimeric receptor complex initiates induction of cytochrome P450 forms. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 11.17 A modular structure of neuronal nitric oxide synthase showing approximate locations of prosthetic groups and cofactors. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 11.18 Model of the dimeric structure of bovine NOSIII showing the protoporphyrin IX (red) and tetrahydrobiopterin (yellow) prosthetic groups. Generated from Protein Data Bank file 2NSE, deposited by C. S. Raman, H. Li, P. Martasek, V. Kral, B. S. Masters, and T. L. Poulos, using WebLab Viewer Lite (Molecular Simulations, Inc.). Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 11.19 Ribbon diagram of nNOS reductase domain derived from its crystal structure. Generated from Protein Data Bank file 1TLL, deposited by E. D. Garcin, C. M. Bruns, S. J. Lloyd, D. J. Hosfield, et al., using WebLab Viewer Lite (Molecular Simulations, Inc.). Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 11.20 Production of nitric oxide. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 11.21 Activation of soluble guanylate cyclase by NO. Redrawn based on figure in Bellamy, T. C. and Garthwaite, J. The receptor-like properties of nitric oxide-activated soluble guanylate cyclase in intact cells. Mol. Cell. Biochem. 230: 165, 2002. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 11.22 NO produced by NOSI in the central nervous system. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 11.23 NO produced by NOSIII in the endothelial cell. Redrawn based on figure by Klabunde, R. E. Cardiovascular Physiology Concepts. This figure can be accessed at http://cvphysiogy.com/ blood%20Flow/BFO11.htm. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.