Volume 54, Issue 1, Pages (July 2008)

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Volume 54, Issue 1, Pages 213-220 (July 2008) Endothelial Rehabilitation: The Impact of Chronic PDE5 Inhibitors on Erectile Function and Protein Alterations in Cavernous Tissue of Diabetic Rats Ling X. De Young, Trustin Domes, KokBin Lim, Jeffery Carson, Gerald B. Brock European Urology Volume 54, Issue 1, Pages 213-220 (July 2008) DOI: 10.1016/j.eururo.2008.02.034 Copyright © 2008 European Association of Urology Terms and Conditions

Fig. 1 Animal distribution. European Urology 2008 54, 213-220DOI: (10.1016/j.eururo.2008.02.034) Copyright © 2008 European Association of Urology Terms and Conditions

Fig. 2 Penile pressure measured in response to electro-stimulation of the cavernous nerve. Bar graph shown the ICP area under curve obtained from seven animals in triplicate of mean±SE. A significant difference was measured between diabetic animals (C1,C2) and diabetic animals exposed to an acute (C1/Vd, C2/Vd) or chronic (6 wk) dose of vardenafil. European Urology 2008 54, 213-220DOI: (10.1016/j.eururo.2008.02.034) Copyright © 2008 European Association of Urology Terms and Conditions

Fig. 3 Representative slides of immunostaining of corpora cavernosa with endothelial cell marker CD31. Note the strong positive staining (dark brown) in the endothelium lining the cavernous sinusoid in the treatment group compared to control (power 400×). European Urology 2008 54, 213-220DOI: (10.1016/j.eururo.2008.02.034) Copyright © 2008 European Association of Urology Terms and Conditions

Fig. 4 Western blot analysis of penile tissue extracts. Left blot shows 140kDa eNOS, 40kDa smooth muscle α-actin, 22kDa Caveolin-1, and 42kDa β-actin (protein loading control). Right panel shows the percentage of protein densitometric value over β-actin of 7 penile tissue extracts from each group. The treatment group demonstrated higher expression of α-actin, eNOS content and eNOS/Caveolin-1 (e/Cave) *: p<0.05. European Urology 2008 54, 213-220DOI: (10.1016/j.eururo.2008.02.034) Copyright © 2008 European Association of Urology Terms and Conditions

Fig. 5 Gel spectral view of the SELDI penile tissue protein profile using the CM10 chip array. Six samples from C2 (left) and Treatment group (right). Spectra from 35 to 75kDa demonstrates an increased intensity of molecular weight 41.9kDa protein moiety in the Treatment group compared with C2 group. European Urology 2008 54, 213-220DOI: (10.1016/j.eururo.2008.02.034) Copyright © 2008 European Association of Urology Terms and Conditions