Rickettsia prowazekii Domina Petric, MD
Free PowerPoint Template from www.brainybetty.com Introduction Rickettsia prowazekii causes classic typhus (typhus exanthematicus, epidemic typhus). This bacteria is obligate intracellular bacteria, coccobacill, gram negative. 11/23/2018 Free PowerPoint Template from www.brainybetty.com
Pathogen Profile Dictionary http://www.ppdictionary.com/bacteria/bwum/prowazekii_files/prowazekii_growing.jpg 11/23/2018 Free PowerPoint Template from www.brainybetty.com
Free PowerPoint Template from www.brainybetty.com Patogenesis Target place for this bacteria are endotel cells of all small blood vessels. 11/23/2018 Free PowerPoint Template from www.brainybetty.com
Free PowerPoint Template from www.brainybetty.com Transmission From louse (Pediculus humanus corporis): there is NO primary lesion or tache noire, eschara. 11/23/2018 Free PowerPoint Template from www.brainybetty.com
Clinical presentation Incubation period: 1 to 2 weeks (usually 12 days). Abrupt onset: fever, severe headache, shivering, malaise, myalgias, arthralgias. 11/23/2018 Free PowerPoint Template from www.brainybetty.com
Clinical presentation After 5 to 7 days from the first symptoms, purple macular rash develops (initially pale on pressure) in axillary pits and upper part of the thorax. After some time rash centrifugally spreads to all body parts. 11/23/2018 Free PowerPoint Template from www.brainybetty.com
Free PowerPoint Template from www.brainybetty.com Purzuit http://4.bp.blogspot.com/-jKd18YbsdD4/Tfe5SY5xmaI/AAAAAAAAHtY/FtNxQIrUa70/s1600/typhus%2Brash.jpg 11/23/2018 Free PowerPoint Template from www.brainybetty.com
Clinical presentation There is usually NO rash on hands, feet and face. There can be symptoms of toxemia if the patient is not treated. Mortality of untreated patients can be from 10% to even 40%. 11/23/2018 Free PowerPoint Template from www.brainybetty.com
Clinical presentation Rare manifestations of the disease: dry cough (with pneumonic infiltration on chest X ray) coma and delirium (CNS affection) myocarditis acute renal insufficiency with full recovery 11/23/2018 Free PowerPoint Template from www.brainybetty.com
Free PowerPoint Template from www.brainybetty.com Treatment Doxycycline 100 mg twice a day 24 to 48 hours after temperature drops. 11/23/2018 Free PowerPoint Template from www.brainybetty.com
Brill-Zinsser´s disease It is late relapse after many years (10 or more years) after the primary infection. Symptoms are similar to those of classic typhus, but milder and shorter in duration. 11/23/2018 Free PowerPoint Template from www.brainybetty.com
Free PowerPoint Template from www.brainybetty.com Literature www.ppdictionary.com Purzuit.com Begovac J. Božinović D. Lisić M. Baršić B. Schönwald S. Infectology, Profil. 11/23/2018 Free PowerPoint Template from www.brainybetty.com