Examples of functional imaging biomarkers in two DCA responders

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Fig. 5. Examples of functional imaging biomarkers in two DCA responders. Examples of functional imaging biomarkers in two DCA responders. (A) MR images showing gadolinium transit time before and after DCA and resolution of the D-shaped septum (arrow) in the heart of patient 3. Note the color scale of the gadolinium transit time: Blue indicates short transit time and increased perfusion; yellow/red indicates long transit time and little/no perfusion at baseline. (B) PA pressure recordings and 18FDG uptake pre- and post-DCA from right heart catheterization and 18FDG-PET-CT, respectively, of patient 10. A shift to the left of the distribution of the 18FDG uptake suggests a decrease in glucose uptake due to decreased glycolysis. Color heat maps show Patlak slope per gram of tissue (score) per voxel in lung sections, indicating the density of high-value voxels (colored in yellow and red, indicating areas of high glucose uptake), overlaid on corresponding CT images. Evangelos D. Michelakis et al., Sci Transl Med 2017;9:eaao4583 Published by AAAS