Amélie Collins, Dan R. Littman Immunity

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Selection and Lineage Specification in the Thymus: Commitment 4-Stalled Amélie Collins, Dan R. Littman Immunity Volume 23, Issue 1, Pages 4-5 (July 2005) DOI: 10.1016/j.immuni.2005.07.003 Copyright © 2005 Elsevier Inc. Terms and Conditions

Figure 1 Postpositive Selection CD4 Expression Is Required for Commitment to the CD4 Lineage (A) Positive selection of CD4+CD8+ thymocytes by MHCII or MHCI leads to MHCII-restricted CD4+ or MHCI-restricted CD8+ T cells through a CD4+8lo intermediate. (B) In β2m-deficient mice, positive selection occurs only on MHCII, and all thymocytes become MHCII-restricted CD4+ T cells. (C) Sarafova and colleagues (Sarafova et al. 2005) find that when positive selection is allowed to occur through CD4/TCR:MHCII interactions followed by CD4 downregulation, all thymocytes become MHCII-restricted CD8+ T cells. Immunity 2005 23, 4-5DOI: (10.1016/j.immuni.2005.07.003) Copyright © 2005 Elsevier Inc. Terms and Conditions