Smart Polymeric Materials

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Presentation transcript:

Smart Polymeric Materials Ipsita Roy, Munishwar Nath Gupta  Chemistry & Biology  Volume 10, Issue 12, Pages 1161-1171 (December 2003) DOI: 10.1016/j.chembiol.2003.12.004

Figure 1 Reversible Precipitation of Eudragit S-100, a Methyl Methacrylate Copolymer, in Response to pH Open circles, Eudragit S-100; open squares, after heating at 60°C for 30 min; and open triangles, after microwave treatment at 60°C for 30 min (our unpublished results). Chemistry & Biology 2003 10, 1161-1171DOI: (10.1016/j.chembiol.2003.12.004)

Figure 2 Manipulation of Intracellular Trafficking by a pH-Responsive Polymer for Drug Delivery (A), Macrophages treated with an E 3 conjugated peptide; (B), lyososomal colocalization of the peptide. The peptide labeled with a fluorescent tag was incubated with macrophages overnight and viewed with a fluorescence microscope (40× magnification). Reproduced from [39] with kind permission of Prof. A.S. Hoffman. Chemistry & Biology 2003 10, 1161-1171DOI: (10.1016/j.chembiol.2003.12.004)

Figure 3 Schematic Diagram of the Swelling/Deswelling Properties of an Interpenetrating Antigen-Antibody Network, as Used in Immunoassays Chemistry & Biology 2003 10, 1161-1171DOI: (10.1016/j.chembiol.2003.12.004)

Figure 4 Plasmid Delivery by a Temperature-Sensitive Polymer The copolymer-plasmid complex was added to cells. Incubation was followed by culturing under various conditions. The transfection efficiency was measured by assaying the enzyme activity. Reprinted from [45] with permission from Elsevier. Chemistry & Biology 2003 10, 1161-1171DOI: (10.1016/j.chembiol.2003.12.004)

Figure 5 Amphiphilic Peptides Can Form Hydrogels of Different Shapes A RAD16 self-assembling oligopeptide forming (A) tape- (B) rope-, and (C) sheet-shaped scaffolds after staining with Congo red. Reprinted from [51] with permission from the author. Original figure kindly supplied by Prof. T.C. Holmes. Chemistry & Biology 2003 10, 1161-1171DOI: (10.1016/j.chembiol.2003.12.004)