High Expression of PHGDH Predicts Poor Prognosis in Non–Small Cell Lung Cancer Jinhong Zhu, Jianqun Ma, Xudong Wang, Tianjiao Ma, Shu Zhang, Wei Wang,

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High Expression of PHGDH Predicts Poor Prognosis in Non–Small Cell Lung Cancer Jinhong Zhu, Jianqun Ma, Xudong Wang, Tianjiao Ma, Shu Zhang, Wei Wang, Xiaoyu Zhou, Jiahai Shi Translational Oncology Volume 9, Issue 6, Pages 592-599 (December 2016) DOI: 10.1016/j.tranon.2016.08.003 Copyright © 2016 Terms and Conditions

Figure 1 Bioinformatics analysis. (A) PHGDH gene. (B) TCGA data indicated a significantly higher PHGDH mRNA expression in tumor tissue than in normal tissues. (Left panel) 108 pairs of tumor and lung tissues (paired t test: P<.0001); (right panel) 108 tumor tissues versus 1014 normal tissues (Student's t test: P<.0001). (C) (left panel) Overall, the KM-plotter showed that patients with PHGDHhigh tumors had significantly shorter survival than those with PHGDHlow tumors (n=1926, log-rank test: P<.001). (Middle panel) PHGDHhigh was significantly associated with reduced survival in adenocarcinoma (n=720, HR=1.38, 95% CI=1.1-1.75; log-rank test: P=.006); (right panel) no significant difference in survival was observed in squamous cell carcinoma (n=524, HR=1.17, 95% CI=0.92-1.48; log-rank test: P=.2). Translational Oncology 2016 9, 592-599DOI: (10.1016/j.tranon.2016.08.003) Copyright © 2016 Terms and Conditions

Figure 2 Immunohistochemical expression of PHGDH in lung tissue microarray cores. (A1, A2) lung adenocarcinoma, strong cytoplasmic expression (red arrow); (B1, B2) squamous cell carcinoma of the lung, strong positive staining in cytoplasm (red arrow); (C1, C2) normal lung tissue, cytoplasm of alveolar epithelial cells, negative staining (green arrow). Original magnification ×40 (bar=500 μm) in A1, B1, and C1; ×400 (bar=50 μm) in A2, B2, and C2. Translational Oncology 2016 9, 592-599DOI: (10.1016/j.tranon.2016.08.003) Copyright © 2016 Terms and Conditions

Figure 3 Significantly higher mRNA expression levels of PHGDH were observed in NSCLC than in tumor adjacent normal tissues (P<.0001). One-step qRT-PCR was used to examine PHGDH mRNA expression levels. Relative mRNA expression of PHGDH was normalized to GAPDH. Translational Oncology 2016 9, 592-599DOI: (10.1016/j.tranon.2016.08.003) Copyright © 2016 Terms and Conditions

Figure 4 Kaplan-Meier survival curves of NSCLC patients. (A) Patients with PHGDHhigh (green) had significantly shortened survival time when compared with those with PHGDHlow tumor (blue). (B) Patients with node metastasis (green) tended to survive shorter than patients without node metastasis (blue). (C) Advanced TNM stages (brown, II; green, III+IV) were significantly correlated with inferior OS. Translational Oncology 2016 9, 592-599DOI: (10.1016/j.tranon.2016.08.003) Copyright © 2016 Terms and Conditions