The Accuracy of Frozen Section Diagnosis of Pulmonary Nodules: Evaluation of Inflation Method during Intraoperative Pathology Consultation with Cryosection

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The Accuracy of Frozen Section Diagnosis of Pulmonary Nodules: Evaluation of Inflation Method during Intraoperative Pathology Consultation with Cryosection.

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The Accuracy of Frozen Section Diagnosis of Pulmonary Nodules: Evaluation of Inflation Method during Intraoperative Pathology Consultation with Cryosection Xianhua Xu, MD, Jin-Haeng Chung, MD, PhD, Sanghoon Jheon, MD, PhD, Sook Whan Sung, MD, PhD, Choon-Taek Lee, MD, PhD, Jae Ho Lee, MD, PhD, Gheeyoung Choe, MD, PhD Journal of Thoracic Oncology Volume 5, Issue 1, Pages 39-44 (January 2010) DOI: 10.1097/JTO.0b013e3181c09f9c Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 The gross appearance of impalpable nodule detected as ground-glass opacity (GGO) in the high resolution computed tomography (HRCT). A, Note a localized pale pinkish lesion in the serial sections of the inflated lung specimen (arrowhead). B, A tiny minute nodule, 3 mm in diameter, was discernible in the cut surface of the lung after inflation. Journal of Thoracic Oncology 2010 5, 39-44DOI: (10.1097/JTO.0b013e3181c09f9c) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Metal molding plate in the cryostat. A, This molding plate is always kept frozen and reduces working time of frozen section. B, Cover the inflated lung tissue with embedding medium. C, Press the lung tissue covered with embedding medium. D, Transfer the frozen lung tissue for cryosection. Journal of Thoracic Oncology 2010 5, 39-44DOI: (10.1097/JTO.0b013e3181c09f9c) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Effect of inflation during cryosection. A, Uninflated lung specimen shows collapsed markedly air spaces. B, Inflated lung tissue with embedding medium demonstrates well preserved parenchymal architecture and open air spaces. Hematoxylin and eosin (HE) staining ×400. Journal of Thoracic Oncology 2010 5, 39-44DOI: (10.1097/JTO.0b013e3181c09f9c) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 4 Frozen section of atypical adenomatous hyperplasia (AAH). Slightly thickened alveolar wall lined by an intermittent single layer of cuboidal cells with apical cytoplasmic snouts. Hematoxylin and eosin (HE) staining ×400. Journal of Thoracic Oncology 2010 5, 39-44DOI: (10.1097/JTO.0b013e3181c09f9c) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 5 Frozen section of sarcoidosis. Well formed conglomerated granulomas were readily recognized. Hematoxylin and eosin (HE) staining ×100. Journal of Thoracic Oncology 2010 5, 39-44DOI: (10.1097/JTO.0b013e3181c09f9c) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 6 Immunohistochemical staining of carcinoembryonic antigen (CEA) using inflated lung tissue during cryosection. The quality of CEA immunoreactivity is as good as that of formalin-fixed lung tissues. immunostain ×400. Journal of Thoracic Oncology 2010 5, 39-44DOI: (10.1097/JTO.0b013e3181c09f9c) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions