Meta-analysis of randomised controlled trials

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Presentation transcript:

Meta-analysis of randomised controlled trials Peter M Rothwell, Gary Robertson The Lancet Volume 350, Issue 9085, Pages 1181-1182 (October 1997) DOI: 10.1016/S0140-6736(05)63832-9 Copyright © 1997 Elsevier Ltd Terms and Conditions

Figure Comparison of estimate of relative treatment effect derived from meta-analysis of early trials (years 1 and 2) with point estimate of treatment effect derived from meta-analysis of subsequent trials in random selection of 26 published meta-analyses Points lying below diagonal line represent overestimation of relative treatment effect by early trials compared with subsequent trials. OR=odds ratio. The Lancet 1997 350, 1181-1182DOI: (10.1016/S0140-6736(05)63832-9) Copyright © 1997 Elsevier Ltd Terms and Conditions