Immunodeficiencies.

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Presentation transcript:

Immunodeficiencies

Diseases caused by defective immune response Immunodeficiencies Diseases caused by defective immune response Disorders of development and/or function of one or more components of the immune system Increased susceptibility to infection and certain types of cancer

Immunodeficiencies Congenital (primary) Acquired (secondary)

Congenital (primary) immunodeficiencies

Congenital immunodeficiencies Caused by genetic defects... in lymphocyte maturation in lymphocyte activation and function in innate immunity Other disorders associated with immunodeficiencies

Congenital immunodeficiencies cause by defects in lymphocyte maturation

B cell immunodeficiencies (agammaglobulinemias) Severe combined immunodeficiencies (SCIDs) T cell immunodeficiencies Defective thymic development (DiGeorge's syndrome)

Congenital immunodeficiencies cause by defects in lymphocyte activation and function

CD40L function in immune response

Congenital immunodeficiencies cause by defects in innate immunity

Defects of innate immunity

Defects of innate immunity

Defects of innate immunity

Immunodeficiencies therapy Congenital (primary) Replacement (e.g. immunoglobulins) Bone marrow transplantation Gene therapy Prophylaxis

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