Volume 191, Issue 1, Pages (January 2014)

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Volume 191, Issue 1, Pages 220-226 (January 2014) Expressed Prostatic Secretion Biomarkers Improve Stratification of NCCN Active Surveillance Candidates: Performance of Secretion Capacity and TMPRSS2:ERG Models Christopher Whelan, Mark Kawachi, David D. Smith, Jennifer Linehan, Gail Babilonia, Rosa Mejia, Timothy Wilson, Steven S. Smith The Journal of Urology Volume 191, Issue 1, Pages 220-226 (January 2014) DOI: 10.1016/j.juro.2013.05.019 Copyright © 2014 American Urological Association Education and Research, Inc. Terms and Conditions

Figure 1 Multivariable logistic regression generated, relative performance ROC curves with baseline serum PSA coupled with secretion capacity biomarkers, including total expressed volume in μl and total RNA in ng in secretion capacity model. Nonzero natural log transformed raw and normalized average values obtained for types II and VI TMPRSS2:ERG fusion expression were used in TMPRSS2:ERG model. Normalization was to amount of RNA used in cDNA reaction. The Journal of Urology 2014 191, 220-226DOI: (10.1016/j.juro.2013.05.019) Copyright © 2014 American Urological Association Education and Research, Inc. Terms and Conditions

Figure 2 Model segregation flow charts of flow and residual risk factors associated with positive or negative test. A, secretion capacity model. B, TMPRSS2:ERG model. The Journal of Urology 2014 191, 220-226DOI: (10.1016/j.juro.2013.05.019) Copyright © 2014 American Urological Association Education and Research, Inc. Terms and Conditions