How I treat thalassemia

Slides:

Advertisements

Similar presentations

Lipid Peroxidation 1 st Year MBBS Lipid Peroxidation refers to the oxidative degradation of lipids.oxidativelipids It is the process in which.

Advertisements

The metabolic effects of excess iron and its assessment 3rd Pan-European Conference on Haemoglobinopathies & Rare Anaemias Limassol, 24 – 26 October 2012.

Pentose Phosphate Pathway Generation of NADPH and Pentoses COURSE TITLE: BIOCHEMISTRY 2 COURSE CODE: BCHT 202 PLACEMENT/YEAR/LEVEL: 2nd Year/Level 4, 2nd.

OXIDATIVE STRESS. INDUCTION OF OXIDATIVE STRESS Glutathione conjugation MalnutritionMutation Phagocytic activation Tissue damageSmoking.

Free radicals and antioxidants in health and disease

Cell Injury Cell and Tissue Adaptation Necrosis and Apoptosis Dr. Raid Jastania.

Cell Injury and Cell Death

General Principles of Cell Injury

Beyond hydroxyurea: new and old drugs in the pipeline for sickle cell disease by Marilyn J. Telen Blood Volume 127(7): February 18, 2016 ©2016 by.

Lecture # 20 CELL INJURY & RESPONSE-3 Dr. Iram Sohail Assistant Professor Pathology.

PESTICIDES-INDUCED OXIDATIVE DAMAGE: POSSIBLE PROTECTION BY Ahmed k. Salama and Omran A. Omran Medical Laboratories Dept., Faculty of Science, Majmaah.

ABL1 Methylation Is a Distinct Molecular Event Associated With Clonal Evolution of Chronic Myeloid Leukemia by Fotis A. Asimakopoulos, Pesach J. Shteper,

by Paul A. Carpenter, Meei-Li Huang, and George B. McDonald

Date of download: 11/12/2016 Copyright © 2016 McGraw-Hill Education. All rights reserved. The respiratory burst in a phagocyte is triggered when a bacterium.

AHMED K. SALAMA AND OMRAN A. OMRAN Medical Laboratories Dept., Faculty of Science, Majmaah University, Kingdom of Saudi Arabia, 1434 H This report is based.

Lipid Peroxidation.

Reactive Oxygen Species in Foods

Traumatic Brain Injury and Mitochondrial Dysfunction

Figure 2. Model illustrating plausible mechanisms mediating anti-inflammatory and adipocyte hypotrophic effects of EPA. We showed here that EPA is able.

Miss.Shuchismita Behera Miss.Sujata Dixit Dr.G.Bulliyya Dr.S.K.Kar

Cellular responses to stress (Adaptations, injury and death) (3 of 5)

Iron overload and chelation therapy in myelodysplastic syndromes

Copyright © 2001 American Medical Association. All rights reserved.

Page 1 Oxidative Stress Assay — Creative BioMart.

Mechanism of Cell Injury

Next-generation leukemia immunotherapy

Oxidative damage, ageing, and life-history evolution: where now?

* Biological Absorption

A Clinical Evaluation of the International Lymphoma Study Group Classification of Non-Hodgkin's Lymphoma Blood Volume 89(11): June 1, 1997 ©1997.

Effects of iron chelation on mitochondrial function.

“Radical” model of thrombosis

Hiroshi Tamura, M. D. , Ph. D. , Yasuhiko Nakamura, M. D. , Ph. D

Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes Alon Mantel, J. Tyson McDonald, Kennedy Goldsborough,

by Zhenping Zhu Blood Volume 108(6): September 15, 2006

Cell membrane proteins from oviductal epithelial cell line protect human spermatozoa from oxidative damage Venus W. Huang, B.Sc., Weie Zhao, M.B.B.S.,

Do reactive oxygen species play a role in myeloid leukemias?

by Annette von Drygalski, and John W. Adamson

CMV: when bad viruses turn good

Oxidative stress in Alzheimer's disease

Deep mining of the RBC proteome

by Douglas D. Ross, Judith E. Karp, Tar T. Chen, and L. Austin Doyle

The aging oocyte—can mitochondrial function be improved?

by Paul A. Carpenter, Meei-Li Huang, and George B. McDonald

ROS Are Good Trends in Plant Science

Shunsuke Furuta, David R.W. Jayne Kidney International

The role of iron and iron chelators in zygomycosis

The role of iron and iron chelators in zygomycosis

POINT: Does Low-Dose Oxygen Expose Patients With COPD to More Radiation-Like Risks Than Patients Without COPD? Yes Vincent J. Kopp, MD, Joseph M. Stavas,

Mechanisms of iron hepatotoxicity

Ashok Kumar Jayavelu, Jennifer N. Moloney, Frank-D. Böhmer, Thomas G

Hypertensive mechanisms of fructose

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease Alexander R. Bogdan, Masaki Miyazawa, Kazunori Hashimoto, Yoshiaki.

Oxidative Stress in the Pathogenesis of Skin Disease

Darcy L. Johannsen, Eric Ravussin Cell Metabolism

Mitochondrial Sterol Oxidation Marks the Spot

Production of reactive oxygen species.

Chromium(VI) Contact Dermatitis: Getting Closer to Understanding the Underlying Mechanisms of Toxicity and Sensitization! Jeroen Buters, Tilo Biedermann

Oxidative damage cell death pathway model.

Hydrogen: another gas with therapeutic potential

Molecular mechanisms of renal hypertrophy: Role of p27Kip1

NERV222 Lecture 3 BIOCHEMISTRY NEUROPSYCHIATRY BLOCK

Erratum in Ledru et al. Alteration of tumor necrosis factor–α T-cell homeostasis following potent antiretroviral therapy: contribution to the development.

Richard A.F. Clark Journal of Investigative Dermatology

Volume 10, Issue 3, Pages (September 2006)

Nathalie Ganne-Carrié, Pierre Nahon Journal of Hepatology

Synergistic combination of valproic acid and oncolytic parvovirus H‐1PV as a potential therapy against cervical and pancreatic carcinomas H‐1PV and VPA.

Oxidative stress is an imbalance between reactive oxygen species (ROS) and antioxidants. a) Under normal conditions there are sufficient antioxidants in.

Mechanisms governing the secondary burst of reactive oxygen species (ROS) and basic pathways of cell death from hyperoxia. 1: Loss of plasma membrane integrity.

Cisplatin (Cis) nephrotoxicity is, in part, related to its uptake by proximal tubular cells. Cisplatin (Cis) nephrotoxicity is, in part, related to its.

On the Road to Bacterial Cell Death

Presentation transcript:

How I treat thalassemia by Eliezer A. Rachmilewitz, and Patricia J. Giardina Blood Volume 118(13):3479-3488 September 29, 2011 ©2011 by American Society of Hematology

Mechanism of IE and hemolysis in thalassemia. Eliezer A. Rachmilewitz, and Patricia J. Giardina Blood 2011;118:3479-3488 ©2011 by American Society of Hematology

Amelioration of free iron species (LPI and LCI) by iron chelators and antioxidants. Amelioration of free iron species (LPI and LCI) by iron chelators and antioxidants. Labile plasma iron (LPI) is penetrating through the cell membrane with a consequent accumulation of labile cell iron (LCI). Both LPI and LCI react with reactive oxygen intermediate (ROI) producing noxious reactive oxygen species (ROS), for example, OH' radicals, which are highly reactive and oxidize DNA, proteins and lipid components of the cell. Deferiprone (DFP) chelates LCI alone or in combination with LPI by Deferiozamine (DFO). Deferasirox (DFX) mainly removes LPI. Eliezer A. Rachmilewitz, and Patricia J. Giardina Blood 2011;118:3479-3488 ©2011 by American Society of Hematology