Prevention of ischemia-reperfusion injury in cardiac surgery: Therapeutic strategies targeting signaling pathways Kay Maeda, MD, PhD, Marc Ruel, MD,

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Presentation transcript:

Prevention of ischemia-reperfusion injury in cardiac surgery: Therapeutic strategies targeting signaling pathways Kay Maeda, MD, PhD, Marc Ruel, MD, MPH, FRCSC The Journal of Thoracic and Cardiovascular Surgery Volume 149, Issue 3, Pages 910-911 (March 2015) DOI: 10.1016/j.jtcvs.2014.11.067 Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Mechanisms involved in ischemia-reperfusion injury and targeting pathways of statins. Ca2+, Calcium ion; ROS, reactive oxygen species; RNS, reactive nitrogen species; PI3K, phosphoinositide 3-kinase; Akt, protein kinase B; eNOS, endothelial nitric oxide synthase; iNOS, induced nitric oxide synthase; NFκB, nuclear factor κB; INF, interferon; MCP, monocyte chemotactic protein; HO, heme oxygenase; IL, interleukin; MIP, macrophage inflammatory proteins; ATP, adenosine triphosphate; ICAM, intracellular cell adhesion molecule; VCAM, vascular cell adhesion molecule; CO, carbon monoxide; NO, nitric oxide; ET, endothelin; NOS, nitric oxide synthase; NADPH, nicotinamide adenine dinucleotide phosphate (reduced form). The Journal of Thoracic and Cardiovascular Surgery 2015 149, 910-911DOI: (10.1016/j.jtcvs.2014.11.067) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions