THE STORY OF FOX VACCINATION AGAINST RABIES USING A RECOMBINANT VACCINIA-RABIES VIRUS Paul-Pierre PASTORET World Organisation for Animal Health
PREVIOUS STORIES THE FIRST ATTEMPTS TO ELIMINATE FOX RABIES INVOLVED CULLING FOXES BY HUNTING AND GASSING THE DENS; THEY WERE UNSUCCESSFUL
PREVIOUS STORIES 2 THE SECOND STEP WAS TO VACCINATE FOXES AGAINST RABIES BY THE ORAL ROUTE USING ATTENUATED STRAINS OF RABIES VIRUS SUCH AS SADB19 STRAIN
PREVIOUS STORIES 3 CONVENTIONALLY ATTENUATED RABIES VIRUS STRAINS ARE STILL PATHOGENIC FOR SOME WILDLIFE SPECIES UNKNOWN SAFETY FOR MAN
PREVIOUS STORIES 4 IN BELGIUM: FIRST TRIALS IN CONFINEMENT WITH ATTENUATED STRAIN SADB19 STRONG OPPOSITION OF VETERINARY AUTHORITIES LARGE-SCALE TRIAL WITH SADB19
THERE WAS ROOM FOR A RECOMBINANT VIRUS THAT COULD BE ADMINISTERED BY THE ORAL ROUTE TO WILDLIFE SPECIES
THE RECOMBINANT VACCINIA-RABIES VACCINE STORY QUALITY EFFICACY SAFETY FOR THE FOX SAFETY FOR OTHER SPECIES SHARING THE SAME ECOSYSTEM
MORE THAN SEVENTY SPECIES TESTED FOR SAFETY NOWADAYS SAFETY FOR HUMANS SAFETY FOR BADGERS SAFETY FOR WILD BOARS MORE THAN SEVENTY SPECIES TESTED FOR SAFETY NOWADAYS
THE RECOMBINANT VACCINIA-RABIES VACCINE STORY 2 WILDLIFE MUST BE VACCINATED BY THE ORAL ROUTE; THE DELIVERY SYSTEM (BAITING) IS OF PRIMARY IMPORTANCE
THE RECOMBINANT VACCINIA-RABIES VACCINE STORY 3 FIELD TRIALS: A SMALL AREA ON A MILITARY CAMP A LARGER AREA IN A CONTAMINATED AREA (2000 km2) THE USE OF THE VACCINE ON THE WHOLE CONTAMINATED AREA IN BELGIUM
THE RECOMBINANT VACCINIA-RABIES VACCINE STORY 4 SURVEILLANCE STUDIES: COLLECTING DEAD FOXES RABIES DIAGNOSIS COLLECTING SAMPLES FROM OTHER WILDLIFE SPECIES TETRACYCLINE DETECTION
THE STORY OF THE RECOMBINANT VACCINIA-RABIES VACCINE 5 THE RESULTS : COMPLETE ELIMINATION OF WILDLIFE RABIES IN BELGIUM SHARP DECREASE OF HUMAN POST-EXPOSURE TREATMENTS ELIMINATION OF RABIES IN IN- CONTACT DOMESTIC ANIMALS INCREASE OF FOX POPULATION