THE STORY OF FOX VACCINATION AGAINST RABIES USING A RECOMBINANT VACCINIA-RABIES VIRUS Paul-Pierre PASTORET World Organisation for Animal Health.

Slides:



Advertisements
Similar presentations
IMMUNOGENICITY OF ERA G 333 STRAIN
Advertisements

Towards the elimination of rabies in Eurasia, Paris, May Efficacy of a square presentation of V-RG vaccine baits in red fox, domestic dog.
NATIONAL VETERINARY RESEARCH INSTITUTE, PULAWY, POLAND Towards the Elimination of Rabies in Eurasia, Paris, May 2007 RABIES SURVEILLANCE IN POLAND.
ATTAINING RACCOON RABIES MANAGEMENT GOALS: HISTORY AND CHALLENGES
The Rabies Situation in Western Europe Alexander I. Wandeler OLF, CFIA Ottawa, Canada.
EPIDEMIOLOGY AND CONTROL OF RABIES IN IRAN. No of persons received PrP.
1 Towards the elimination of Rabies in Eurasia Jean Blancou, WOAH, May
WHO/MZCP RABIES in the MIDDLE EAST A. Seimenis, D.V.M. Director, WHO/Mediterranean Zoonoses Control Centre ATHENS, GREECE
“One Health” pulling Animal Health and Public Health together
Development of Vaccine Approaches for Bovine Tuberculosis in Free- Ranging White-tailed Deer Mitchell Palmer, Ray Waters, Tyler Thacker National Animal.
INTEGRATED RABIES EPIDEMIOLOGY IN REMOTE INUIT COMMUNITIES IN QUÉBEC, CANADA: A “ONE HEALTH” APPROACH C. Aenishaenslin, A. Simon, T. Forde, A. Ravel, J-F.
The Epidemiology of Animal Rabies and Public Health Implications Dr Paul Bartlett MPH., DVM., Ph. D. VM 544 Veterinary Preventive Medicine.
ASF in the EU Vilnius 09/12/14 This presentation does not necessarily represent the views of the European Commission.
Philip M. Kitala 1 and Stella Kiambi 2 1 University of Nairobi Dept Public Health, Pharm and Toxi 2 Ministry.
Do You Know Do you know an animal that’s red Do you know an animal that is trained to hunt.
Rabies Control Program
Wildlife Management and Vector Control During Livestock or Poultry Disease Outbreaks.
Data Requirements for Field Release and Monitoring Jon Knight Imperial College London
Terry Kotrla, MS, MT(ASCP)BB
Making Vaccines.
Dr Hannah Kibuuka Makerere University Walter Reed Project Presentation at the Uganda Medical Association-Uganda Veterinary Association joint conference.
Adapted from: Project Lead The Way Making Vaccines powerpoint
Aujeszky-disease.
Yr 8 APP – AF3a Do Badgers Infect Cattle With TB? Imagine you are a government official and you have to decide whether culling is the best move. AIM Select.
Kenny V. Brock BVDV vaccination and prevention of reproductive
13 years in 20 minutes: Badger vaccine development and efficacy Dr Mark A. Chambers TB Science Lead Animal Health and Veterinary Laboratories Agency, U.K.
Epidemiology of rabies in skunks in Texas Tom J. Sidwa, D.V.M. Zoonosis Control Branch Texas Department of State Health Services.
Charles-Miller Wabeno, MPH student Walden University PUBH Instructor: Dr. Howard Rubin Spring, 2010.
METHODS TO STUDY DRUG SAFETY PROBLEMS animal experiments clinical trials epidemiological methods –spontaneous reporting case reports case series –Post-Marketing.
One Health Initiative: Global Clearinghouse for Activities Involving Rabies and Other Zoonoses Jack Woodall PhD & the OHI Team Bruce Kaplan DVM Laura Kahn.
Surveillance During Animal Disease Emergencies Overview.
By Dr. Victoria J. Cabrera DVM.  Is a lethal encephalitis cause by a virus in the family Rhabdoviridae genus Lyssavirus  Exposure occurs through the.
14. Immunodiagnosis, Immunotherapy & Vaccination 王 家 鑫, MD College of Veterinary Medicine.
Developing policy for the use of TB vaccines in badgers and cattle in Wales Christianne Glossop CVO Wales Vaccination in the control of bovine tuberculosis.
Day CREATING A WORLD THAT IS SAFE AND SUSTAINABLE FOR WILDLIFE AND SOCIETY Avian Influenza in Wild Birds Matching goals and methods.
The Rabies Situation in Eastern Europe National Reference Laboratory for Rabies, State Veterinary Institute, Liberec, Czech Republic Oldřich Matouch.
Making Vaccines. Effective Vaccines Have low levels of side effects or toxicity. Protect against exposure to natural, or wild forms of the pathogen. Should.
Risk of rabies introduction by non- commercial movement of pets Case study: ROMANIA.
What Every Veterinarian Needs to Know about Rabies Jamie Snow DVM,MPH Wyoming Department of Health.
CATEGORY: VACCINES & THERAPEUTICS HIV-1 Vaccines Shokouh Makvandi-Nejad, University of Oxford, UK HIV-1 Vaccines © The copyright for this work resides.
$1 Million $500,000 $100,000 $50,000 $25,000 $10,000 $5,000 $1,000.
Health and Consumers Health and Consumers Observations from FVO audits of monitoring and eradication programmes for diseases affecting wildlife Lena Englund.
Rabies: What kids need to know! Slides provided by: Wyoming Department Health Preventive Health and Safety Division.
Sokoine University of Agriculture The UBS Rabies Surveillance Project
RABIES: Status, Control and Strategy in Croatia Ivana Lohman, DVM Ministry of Agriculture, Fisheries and Rural Development Veterinary Directorate.
Poultry Federation Food Safety Conference Dr. Jack Shere Acting Deputy Administrator U.S. Department of Agriculture Animal and Plant Health Inspection.
Prof Ulf Magnusson Department of Clinical Sciences Faculty of
MORBIDITY DATA: REGISTRIES AND SURVEILLANCE
HIV-1 Vaccines Shokouh Makvandi-Nejad, University of Oxford, UK
Moral Monday BW Should patients be given refunds when a vaccine doesn’t work?
Better Training for Safer Food Initiative
IMMUNITY © 2016 Paul Billiet ODWS.
Morbidity data: registries, surveillance
INTRODUCTION The oral route of drugs administration is the most important method of administering drugs for systemic effects.
Rabies.
Making Vaccines.
Dr Paul T Francis, MD Community Medicine College of Medicine, Zawia
US Army Medical Research and Materiel Command
INTAKE AND STABILITY OF RABIES VACCINE BAITS
BIODIVERSITY AND EMERGING INFECTIONS
Quarantine and health certification in aquaculture
Raccoon Rabies in West Virginia: What Does the Data Tell Us?
Scientific and Technical Department OIE
Reverse Vaccinology: Developing Vaccines in the Era of Genomics
Raccoon Rabies in West Virginia: What Does the Data Tell Us?
Twinning workshop, Cairo
Bats.
Varicella Vaccine Efficacy Estimates
Effectiveness of vaccination for influenza in the current and any of the 3 previous seasons in preventing nonsevere and severe cases of influenza by season,
« Poultry HPAI Vaccination: Decision Making »
Presentation transcript:

THE STORY OF FOX VACCINATION AGAINST RABIES USING A RECOMBINANT VACCINIA-RABIES VIRUS Paul-Pierre PASTORET World Organisation for Animal Health

PREVIOUS STORIES THE FIRST ATTEMPTS TO ELIMINATE FOX RABIES INVOLVED CULLING FOXES BY HUNTING AND GASSING THE DENS; THEY WERE UNSUCCESSFUL

PREVIOUS STORIES 2 THE SECOND STEP WAS TO VACCINATE FOXES AGAINST RABIES BY THE ORAL ROUTE USING ATTENUATED STRAINS OF RABIES VIRUS SUCH AS SADB19 STRAIN

PREVIOUS STORIES 3 CONVENTIONALLY ATTENUATED RABIES VIRUS STRAINS ARE STILL PATHOGENIC FOR SOME WILDLIFE SPECIES UNKNOWN SAFETY FOR MAN

PREVIOUS STORIES 4 IN BELGIUM: FIRST TRIALS IN CONFINEMENT WITH ATTENUATED STRAIN SADB19 STRONG OPPOSITION OF VETERINARY AUTHORITIES LARGE-SCALE TRIAL WITH SADB19

THERE WAS ROOM FOR A RECOMBINANT VIRUS THAT COULD BE ADMINISTERED BY THE ORAL ROUTE TO WILDLIFE SPECIES

THE RECOMBINANT VACCINIA-RABIES VACCINE STORY QUALITY EFFICACY SAFETY FOR THE FOX SAFETY FOR OTHER SPECIES SHARING THE SAME ECOSYSTEM

MORE THAN SEVENTY SPECIES TESTED FOR SAFETY NOWADAYS SAFETY FOR HUMANS SAFETY FOR BADGERS SAFETY FOR WILD BOARS MORE THAN SEVENTY SPECIES TESTED FOR SAFETY NOWADAYS

THE RECOMBINANT VACCINIA-RABIES VACCINE STORY 2 WILDLIFE MUST BE VACCINATED BY THE ORAL ROUTE; THE DELIVERY SYSTEM (BAITING) IS OF PRIMARY IMPORTANCE

THE RECOMBINANT VACCINIA-RABIES VACCINE STORY 3 FIELD TRIALS: A SMALL AREA ON A MILITARY CAMP A LARGER AREA IN A CONTAMINATED AREA (2000 km2) THE USE OF THE VACCINE ON THE WHOLE CONTAMINATED AREA IN BELGIUM

THE RECOMBINANT VACCINIA-RABIES VACCINE STORY 4 SURVEILLANCE STUDIES: COLLECTING DEAD FOXES RABIES DIAGNOSIS COLLECTING SAMPLES FROM OTHER WILDLIFE SPECIES TETRACYCLINE DETECTION

THE STORY OF THE RECOMBINANT VACCINIA-RABIES VACCINE 5 THE RESULTS : COMPLETE ELIMINATION OF WILDLIFE RABIES IN BELGIUM SHARP DECREASE OF HUMAN POST-EXPOSURE TREATMENTS ELIMINATION OF RABIES IN IN- CONTACT DOMESTIC ANIMALS INCREASE OF FOX POPULATION