Cancer Driver Log (CanDL)

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Cancer Driver Log (CanDL) Senthilkumar Damodaran, Jharna Miya, Esko Kautto, Eliot Zhu, Eric Samorodnitsky, Jharna Datta, Julie W. Reeser, Sameek Roychowdhury The Journal of Molecular Diagnostics Volume 17, Issue 5, Pages 554-559 (September 2015) DOI: 10.1016/j.jmoldx.2015.05.002 Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

Figure 1 Prevalence of the Cancer Drive Log (CanDL) mutations in cBioPortal. The color shade in each box corresponds to the number of samples in cBioPortal that had at least one CanDL mutation for a given gene and tumor type. The gradient scale is on the right. Genes were sorted in descending order, and the top 10 are represented on the y axis. The x axis represents tumor type. The Journal of Molecular Diagnostics 2015 17, 554-559DOI: (10.1016/j.jmoldx.2015.05.002) Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

Figure 2 Distribution of the Cancer Driver Log (CanDL) mutations across protein domains. The distribution of domains for mutations that are listed in CanDL, as defined by InterPro database, are shown. The y axis (// denotes break) represents the percentage of genes. Protein kinase (PK) domain mutations were the most common followed by small GTP-binding (SGBP) domain mutations. ATF, Armadillo-type fold; B4.1, band 4.1 domain; CF, coagulation factor 5/8 C-terminal type domain; EGFR, epidermal growth factor receptor, L domain; FB, T3, fibronectin type III; FL, CR, Furin-like cysteine-rich domain; GPAS, HI, G-protein α-subunit, helical insertion; GPCR, G protein coupled receptor; F2L, family 2-like; IDL, isopropylmalate dehydrogenase–like domain; IG I-S, immunoglobulin I set; IG S-2, immunoglobulin subtype 2; IGFB, insulin-like growth factor binding protein, N-terminal; NHR, LB, nuclear hormone receptor, ligand-binding; P3K, C2, phosphatidylinositol 3-kinase, C2 domain; PH, pleckstrin homology domain; PH, CD, phosphatidylinositol 3-/4-kinase, catalytic domain; PI3K ABD, phosphatidylinositol 3-kinase adaptor-binding domain; PIK-R, PIK-related kinase; PK, protein kinase domain; PKL, protein kinase–like domain; RGTPase, Rho GTPase activation protein; SET, SET domain; SGBP, small GTP-binding protein domain; SH2, SH2 domain; TIR, Toll/interleukin-1 receptor homology domain. The Journal of Molecular Diagnostics 2015 17, 554-559DOI: (10.1016/j.jmoldx.2015.05.002) Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions