The broad spectrum of interepithelial junctions in skin and lung

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Presentation transcript:

The broad spectrum of interepithelial junctions in skin and lung Jeannette I. Kast, BSc, Kerstin Wanke, MSc, Michael B. Soyka, MD, Paulina Wawrzyniak, MSc, Deniz Akdis, BSc, Külli Kingo, MD, PhD, Ana Rebane, PhD, Cezmi A. Akdis, MD Journal of Allergy and Clinical Immunology Volume 130, Issue 2, Pages 544-547.e4 (August 2012) DOI: 10.1016/j.jaci.2012.04.044 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Junctional complexes of epithelial cells and protein composition of TJs. A, Scheme of the junctional complexes in epithelial cells: TJs, adherens junction, desmosomes, and gap junctions. B, Protein composition of TJ: transmembrane proteins include junctional adhesion molecules (JAMs), claudin family, Marvel family members, and adaptor proteins. MAGI, Membrane-associated guanylate kinase inverted; MUPP1, multi-PDZ domain containing protein 1; ZO, zonula occludens. Journal of Allergy and Clinical Immunology 2012 130, 544-547.e4DOI: (10.1016/j.jaci.2012.04.044) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Taqman low -density array microfluidic card mRNA expression profile of TJs in the skin and lung tissue, ALI, and monolayer cultures of NHBE cells and primary KC lines. mRNA expression of transmembrane TJ proteins (A and B), of other cell junctions, such as desmosomes, adherens junctions, and gap junctions (C and D), and of junctional adaptor proteins (E and F). Lung tissue, n = 5; skin tissue, n = 4; NHBE ALI, n = 4; KC ALI, n = 4; NHBE monolayer, n = 4; and KC monolayer, n = 4, were investigated. Mean ± SEM is displayed. CMLP, CXADR-like membrane protein (ASAM); JAM, junctional adhesion molecules; KC, keratinocyte; MAGI, membrane-associated guanylate kinase inverted; MUPP1, multi-PDZ domain containing protein 1; NHBE, normal human bronchial epithelial; PATJ, inaD-like protein (INADL); ZO, zonula occludens. Journal of Allergy and Clinical Immunology 2012 130, 544-547.e4DOI: (10.1016/j.jaci.2012.04.044) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions