IL-11: Insights in asthma from overexpression transgenic modeling

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Presentation transcript:

IL-11: Insights in asthma from overexpression transgenic modeling Tao Zheng, MDa,b, Zhou Zhu, MD, PhDa, Jingming Wang, PhDa, Robert J. Homer, MD, PhDc,d, Jack A. Elias, MDa Journal of Allergy and Clinical Immunology Volume 108, Issue 4, Pages 489-496 (October 2001) DOI: 10.1067/mai.2001.118510 Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 1 Schematic illustration shows the stimuli that induce IL-11 production, the cells that produce IL-11 in the lung, and the major effector functions of IL-11 in pulmonary and extrapulmonary tissues. Journal of Allergy and Clinical Immunology 2001 108, 489-496DOI: (10.1067/mai.2001.118510) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 2 Components of the lung-targeted overexpression transgenic systems used in the investigation of IL-11. The single-construct constitutive system is presented in A ; the dual-construct inducible system is presented in B . Journal of Allergy and Clinical Immunology 2001 108, 489-496DOI: (10.1067/mai.2001.118510) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 3 Histologic features of CC10–IL-11 transgenic mice. The photomicrographs compare transgene-negative and transgene-positive mice through use of hematoxylin-eosin and Trichrome evaluations. Airway fibrosis and enlarged alveoli are readily apparent. Journal of Allergy and Clinical Immunology 2001 108, 489-496DOI: (10.1067/mai.2001.118510) Copyright © 2001 Mosby, Inc. Terms and Conditions