Changing Chromatin Fiber Conformation by Nucleosome Repositioning

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Presentation transcript:

Changing Chromatin Fiber Conformation by Nucleosome Repositioning Oliver Müller, Nick Kepper, Robert Schöpflin, Ramona Ettig, Karsten Rippe, Gero Wedemann Biophysical Journal Volume 107, Issue 9, Pages 2141-2150 (November 2014) DOI: 10.1016/j.bpj.2014.09.026 Copyright © 2014 Biophysical Society Terms and Conditions

Figure 1 Three-dimensional visualization of the chromatin fiber models used in this work: (A) CL, (B) CLS, (C) ID; DNA is colored in blue, histones in shades of red where the shade denotes the fiber repeats. To see this figure in color, go online. Biophysical Journal 2014 107, 2141-2150DOI: (10.1016/j.bpj.2014.09.026) Copyright © 2014 Biophysical Society Terms and Conditions

Figure 2 Mean fiber bending angle (A) and standard deviation (B) of the CL (red circles), CLS (black squares), and ID fiber models (blue triangles) as a function of nucleosome displacement d. To see this figure in color, go online. Biophysical Journal 2014 107, 2141-2150DOI: (10.1016/j.bpj.2014.09.026) Copyright © 2014 Biophysical Society Terms and Conditions

Figure 3 Mean total fiber energy differences ΔE of the CL (red circles), CLS (black squares), and ID fiber models (blue triangles) as a function of nucleosome displacement d. To see this figure in color, go online. Biophysical Journal 2014 107, 2141-2150DOI: (10.1016/j.bpj.2014.09.026) Copyright © 2014 Biophysical Society Terms and Conditions

Figure 4 Nucleosomal contact maps of the CL, CLS, and ID fiber (top, center, and bottom row, respectively) for a subset of nucleosomal displacements (bottom). Each map shows the contact probabilities of distinct pairs of nucleosomes i and j. The repositioned nucleosome is located at index 51. The probability is expressed as a percentage. Note the logarithmic probability scale, with white meaning a probability <0.1. The region of the diagonal from top left to bottom right shows the interactions between each nucleosome and its direct neighbors, and the region around the antidiagonal shows interactions between nucleosomes that reside in distant sites of the fiber. To see this figure in color, go online. Biophysical Journal 2014 107, 2141-2150DOI: (10.1016/j.bpj.2014.09.026) Copyright © 2014 Biophysical Society Terms and Conditions